Cargando…

Dexmedetomidine Protects Human Renal Tubular Epithelial HK-2 Cells against Hypoxia/Reoxygenation Injury by Inactivating Endoplasmic Reticulum Stress Pathway

OBJECTIVE: The study was aimed to investigate the effects and potential mechanisms of Dexmedetomidine (Dex) on hypoxia/reoxygenation (H/R) injury in human renal tubular epithelial HK-2 cells. MATERIALS AND METHODS: In this experimental study, HK-2 cells were divided into four groups: control group,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhai, Mingyu, Han, Mingming, Huang, Xiang, Kang, Fang, Yang, Chengwei, Li, Juan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royan Institute 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405080/ https://www.ncbi.nlm.nih.gov/pubmed/34455722 http://dx.doi.org/10.22074/cellj.2021.7220

Ejemplares similares

Glaucocalyxin A Ameliorates Hypoxia/Reoxygenation-Induced Injury in Human Renal Proximal Tubular Epithelial Cell Line HK-2 Cells
por: Hosohata, Keiko, et al.
Publicado: (2021)

Berberine protects human renal proximal tubular cells from hypoxia/reoxygenation injury via inhibiting endoplasmic reticulum and mitochondrial stress pathways
por: Yu, Wenli, et al.
Publicado: (2013)

MicroRNA-423-5p facilitates hypoxia/reoxygenation-induced apoptosis in renal proximal tubular epithelial cells by targeting GSTM1 via endoplasmic reticulum stress
por: Yuan, Xiao-Peng, et al.
Publicado: (2017)

Hypoxia-reoxygenation induced necroptosis in cultured rat renal tubular epithelial cell line
por: Zhu, Changlai, et al.
Publicado: (2018)

Prohibitin is associated with antioxidative protection in hypoxia/reoxygenation-induced renal tubular epithelial cell injury
por: Zhou, Tian-Biao, et al.
Publicado: (2013)

Irisin protects cardiomyocytes against hypoxia/reoxygenation injury via attenuating AMPK mediated endoplasmic reticulum stress
por: Yue, Rongchuan, et al.
Publicado: (2022)

Augmenter of Liver Regeneration Alleviates Renal Hypoxia-Reoxygenation Injury by Regulating Mitochondrial Dynamics in Renal Tubular Epithelial Cells
por: Long, Rui-ting, et al.
Publicado: (2019)

miR-30a-5p inhibits hypoxia/reoxygenation-induced oxidative stress and apoptosis in HK-2 renal tubular epithelial cells by targeting glutamate dehydrogenase 1 (GLUD1)
por: He, Yangbiao, et al.
Publicado: (2020)

Calreticulin Translocation Aggravates Endoplasmic Reticulum Stress-associated Apoptosis during Cardiomyocyte Hypoxia/Reoxygenation
por: Xu, Fei-Fei, et al.
Publicado: (2015)

Baicalein protects renal tubular epithelial cells againsthypoxia-reoxygenation injury
por: Chen, Chun, et al.
Publicado: (2018)

The role of HIF-1 in up-regulating MICA expression on human renal proximal tubular epithelial cells during hypoxia/reoxygenation
por: Luo, Lei, et al.
Publicado: (2010)

Pioglitazone Attenuates Reoxygenation Injury in Renal Tubular NRK-52E Cells Exposed to High Glucose via Inhibiting Oxidative Stress and Endoplasmic Reticulum Stress
por: Zou, Cong, et al.
Publicado: (2020)

Mechanism of interactions between endoplasmic reticulum stress and autophagy in hypoxia/reoxygenation-induced injury of H9c2 cardiomyocytes
por: Guan, Gaopeng, et al.
Publicado: (2019)

Dexmedetomidine attenuates hypoxia/reoxygenation injury in primary neonatal rat cardiomyocytes
por: Peng, Ke, et al.
Publicado: (2017)

Propofol Attenuates Hypoxia/Reoxygenation-Induced Apoptosis and Autophagy in HK-2 Cells by Inhibiting JNK Activation
por: Wang, Huaxin, et al.
Publicado: (2019)

Role of endoplasmic reticulum oxidase 1α in H9C2 cardiomyocytes following hypoxia/reoxygenation injury
por: Lai, Lina, et al.
Publicado: (2020)

The Mechanisms of the Herbal Components of CRSAS on HK-2 Cells in a Hypoxia/Reoxygenation Model Based on Network Pharmacology
por: Ye, Naijing, et al.
Publicado: (2020)

Salidroside mitigates hypoxia/reoxygenation injury by alleviating endoplasmic reticulum stress-induced apoptosis in H9c2 cardiomyocytes
por: Sun, Meng-Yao, et al.
Publicado: (2018)

Rosuvastatin protects PC12 cells from hypoxia/reoxygenation-induced injury by inhibiting endoplasmic reticulum stress-induced apoptosis
por: Gao, Yu, et al.
Publicado: (2021)

Botulinum toxin type A activates protective autophagy by modulating endoplasmic reticulum stress in hypoxia/reoxygenation-treated endothelial cells
por: Zhao, Yinhua, et al.
Publicado: (2023)

Dexmedetomidine protects cardiomyocytes against hypoxia/reoxygenation injury via multiple mechanisms
por: Cai, Shunv, et al.
Publicado: (2021)

Reconstitution of the tubular endoplasmic reticulum network with purified components
por: Powers, Robert E., et al.
Publicado: (2017)

Endoplasmic Reticulum Stress Mediates Renal Tubular Vacuolation in BK Polyomavirus-Associated Nephropathy
por: Zhao, Guo-Dong, et al.
Publicado: (2022)

Signal transduction involved in lipoxin A(4)-induced protection of tubular epithelial cells against hypoxia/reoxygenation injury
por: Wu, Sheng-Hua, et al.
Publicado: (2017)

The Role of Indoleamine 2,3-Dioxygenase in Renal Tubular Epithelial Cells Senescence under Anoxia or Reoxygenation
por: Eleftheriadis, Theodoros, et al.
Publicado: (2021)

Inhibition of Renal Tubular Epithelial Mesenchymal Transition and Endoplasmic Reticulum Stress-Induced Apoptosis with Shenkang Injection Attenuates Diabetic Tubulopathy
por: Wang, Wen-Wen, et al.
Publicado: (2021)

Dexmedetomidine at a dose of 1 µM attenuates H9c2 cardiomyocyte injury under 3 h of hypoxia exposure and 3 h of reoxygenation through the inhibition of endoplasmic reticulum stress
por: Zhu, Zhipeng, et al.
Publicado: (2021)

Protective effects of dexmedetomidine on hypoxia/reoxygenation injury in cardiomyocytes by regulating the CHOP signaling pathway
por: Shi, Xiaoqiao, et al.
Publicado: (2020)

Pyruvate alleviates high glucose‐induced endoplasmic reticulum stress and apoptosis in HK‐2 cells
por: Zhang, Xiao Meng, et al.
Publicado: (2020)

Histone deacetylase 8 protects human proximal tubular epithelial cells from hypoxia-mimetic cobalt- and hypoxia/reoxygenation-induced mitochondrial fission and cytotoxicity
por: Ha, Soon-Duck, et al.
Publicado: (2018)

Involvement of Endoplasmic Reticulum Stress in Albuminuria Induced Inflammasome Activation in Renal Proximal Tubular Cells
por: Fang, Li, et al.
Publicado: (2013)

Pinocembrin ameliorates lipopolysaccharide-induced HK-2 cell apoptosis and inflammation by regulating endoplasmic reticulum stress
por: Zhang, Yu, et al.
Publicado: (2022)

Remifentanil attenuates endoplasmic reticulum stress and inflammatory injury in LPS-induced damage in HK-2 cells
por: Yan, Yixiu, et al.
Publicado: (2022)

Immunosuppressive calcineurin inhibitor cyclosporine A induces proapoptotic endoplasmic reticulum stress in renal tubular cells
por: Yilmaz, Duygu Elif, et al.
Publicado: (2022)

Reoxygenation induces reactive oxygen species production and ferroptosis in renal tubular epithelial cells by activating aryl hydrocarbon receptor
por: Eleftheriadis, Theodoros, et al.
Publicado: (2021)

Inhibition of Malate Dehydrogenase-2 Protects Renal Tubular Epithelial Cells from Anoxia-Reoxygenation-Induced Death or Senescence
por: Eleftheriadis, Theodoros, et al.
Publicado: (2022)

AMP-Activated Protein Kinase Activation during Cardioplegia-Induced Hypoxia/Reoxygenation Injury Attenuates Cardiomyocytic Apoptosis via Reduction of Endoplasmic Reticulum Stress
por: Yeh, Chi-Hsiao, et al.
Publicado: (2010)

Dexmedetomidine alleviates insulin resistance in hepatocytes by reducing endoplasmic reticulum stress
por: Liu, Fanfan, et al.
Publicado: (2019)

CAND1 regulates lunapark for the proper tubular network of the endoplasmic reticulum
por: Kajiho, Hiroaki, et al.
Publicado: (2019)

Circ_0023404 sponges miR‐136 to induce HK‐2 cells injury triggered by hypoxia/reoxygenation via up‐regulating IL‐6R
por: Xu, Yong, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_psulo2hmibvp4uovqpev36t8ot