Analysis of annexin-A1 in the macrophages and apoptotic cells of patients with cutaneous leishmaniasis

INTRODUCTION: This study aimed to determine the number of macrophages and apoptotic cells and perform annexin-A1 detection in patients with leishmaniasis. METHODS: Patients with Leishmania infection were admitted to Júlio Müller University Hospital. RESULTS: The number of apoptotic cells was higher...

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Autores principales: Pona, Mariana Nascimento, Dietrich, Jordhana Mendonça, da Silva, Joselina Maria, da Silva, Helen Aguiar Lemes, Hueb, Marcia, Damazo, Amilcar Sabino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405212/
https://www.ncbi.nlm.nih.gov/pubmed/34431955
http://dx.doi.org/10.1590/0037-8682-0756-2020
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author Pona, Mariana Nascimento
Dietrich, Jordhana Mendonça
da Silva, Joselina Maria
da Silva, Helen Aguiar Lemes
Hueb, Marcia
Damazo, Amilcar Sabino
author_facet Pona, Mariana Nascimento
Dietrich, Jordhana Mendonça
da Silva, Joselina Maria
da Silva, Helen Aguiar Lemes
Hueb, Marcia
Damazo, Amilcar Sabino
author_sort Pona, Mariana Nascimento
collection PubMed
description INTRODUCTION: This study aimed to determine the number of macrophages and apoptotic cells and perform annexin-A1 detection in patients with leishmaniasis. METHODS: Patients with Leishmania infection were admitted to Júlio Müller University Hospital. RESULTS: The number of apoptotic cells was higher in the exudative granulomatous reaction. The exudative cellular reaction displayed higher levels of annexin-A1 detection in macrophages and apoptotic cells. The correlation between annexin-A1 detection in apoptotic cells and macrophages was observed in exudative necrotic reaction and exudative necrotic-granulomatous reaction. CONCLUSIONS: Our data demonstrate the relevance of annexin-A1 in the regulation of apoptosis and phagocytosis in leishmaniasis.
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spelling pubmed-84052122021-09-10 Analysis of annexin-A1 in the macrophages and apoptotic cells of patients with cutaneous leishmaniasis Pona, Mariana Nascimento Dietrich, Jordhana Mendonça da Silva, Joselina Maria da Silva, Helen Aguiar Lemes Hueb, Marcia Damazo, Amilcar Sabino Rev Soc Bras Med Trop Short Communication INTRODUCTION: This study aimed to determine the number of macrophages and apoptotic cells and perform annexin-A1 detection in patients with leishmaniasis. METHODS: Patients with Leishmania infection were admitted to Júlio Müller University Hospital. RESULTS: The number of apoptotic cells was higher in the exudative granulomatous reaction. The exudative cellular reaction displayed higher levels of annexin-A1 detection in macrophages and apoptotic cells. The correlation between annexin-A1 detection in apoptotic cells and macrophages was observed in exudative necrotic reaction and exudative necrotic-granulomatous reaction. CONCLUSIONS: Our data demonstrate the relevance of annexin-A1 in the regulation of apoptosis and phagocytosis in leishmaniasis. Sociedade Brasileira de Medicina Tropical - SBMT 2021-08-20 /pmc/articles/PMC8405212/ /pubmed/34431955 http://dx.doi.org/10.1590/0037-8682-0756-2020 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Short Communication
Pona, Mariana Nascimento
Dietrich, Jordhana Mendonça
da Silva, Joselina Maria
da Silva, Helen Aguiar Lemes
Hueb, Marcia
Damazo, Amilcar Sabino
Analysis of annexin-A1 in the macrophages and apoptotic cells of patients with cutaneous leishmaniasis
title Analysis of annexin-A1 in the macrophages and apoptotic cells of patients with cutaneous leishmaniasis
title_full Analysis of annexin-A1 in the macrophages and apoptotic cells of patients with cutaneous leishmaniasis
title_fullStr Analysis of annexin-A1 in the macrophages and apoptotic cells of patients with cutaneous leishmaniasis
title_full_unstemmed Analysis of annexin-A1 in the macrophages and apoptotic cells of patients with cutaneous leishmaniasis
title_short Analysis of annexin-A1 in the macrophages and apoptotic cells of patients with cutaneous leishmaniasis
title_sort analysis of annexin-a1 in the macrophages and apoptotic cells of patients with cutaneous leishmaniasis
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405212/
https://www.ncbi.nlm.nih.gov/pubmed/34431955
http://dx.doi.org/10.1590/0037-8682-0756-2020
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