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Interventional Clinical Trials on Diabetic Peripheral Neuropathy: A Retrospective Analysis
AIMS/INTRODUCTION: Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes. At present, there is no comprehensive summary of the clinical trials related to DPN. In this article, we summarized the basic characteristics of the interventional clinical trials pertaining to DPN t...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405224/ https://www.ncbi.nlm.nih.gov/pubmed/34471381 http://dx.doi.org/10.2147/JPR.S320364 |
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author | Wang, Mengmeng Zhang, Zepeng Mi, Jia Wang, Guoqiang Tian, Lulu Zhao, Yunyun Li, Xiaomin Li, Xiangyan Wang, Xiuge |
author_facet | Wang, Mengmeng Zhang, Zepeng Mi, Jia Wang, Guoqiang Tian, Lulu Zhao, Yunyun Li, Xiaomin Li, Xiangyan Wang, Xiuge |
author_sort | Wang, Mengmeng |
collection | PubMed |
description | AIMS/INTRODUCTION: Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes. At present, there is no comprehensive summary of the clinical trials related to DPN. In this article, we summarized the basic characteristics of the interventional clinical trials pertaining to DPN to determine the current status of research in this field and the existing issues. MATERIALS AND METHODS: We searched the World Health Organization International Clinical Trial Registration Platform (ICTRP), PubMed and Web of Science for clinical trials from 2005 to April 2021 and extracted 149 registered and 459 published clinical trials on DPN. We summarized the characteristics of the clinical trials, including the source registration, recruitment status, stage, age group, allocation method, intervention, end point classification, funding source, and treatment. RESULTS: After excluding noninterventional and nontreatment trials, 149 registered clinical trials out of 292 records from 12 registration centers and 459 published articles were included in this study. Among the registered trials, 43% had been completed, and 34.4% had been published in peer-reviewed journals. Among these trials, more than half used random allocation and blinded placebo-controlled methodologies. A total of 40.3% of the trials were multicenter studies, 63.8% of the treatments were drug therapies, and the endpoint classifications of 49% were efficacy and safety. Of the 459 published interventional clinical trials on DPN, 69.7% of the trials used drug treatments; more than half were randomized, double-blind, placebo-controlled clinical trials; 94.1% had positive outcomes; 46.4% had a target size of 50; and 22.9% were multicenter. CONCLUSION: This paper systematically summarizes the current status of interventional trials on DPN registered in the ICTRP and published clinical trials and provides a reference for the development of high-quality intervention strategies for DPN in the future. |
format | Online Article Text |
id | pubmed-8405224 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-84052242021-08-31 Interventional Clinical Trials on Diabetic Peripheral Neuropathy: A Retrospective Analysis Wang, Mengmeng Zhang, Zepeng Mi, Jia Wang, Guoqiang Tian, Lulu Zhao, Yunyun Li, Xiaomin Li, Xiangyan Wang, Xiuge J Pain Res Original Research AIMS/INTRODUCTION: Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes. At present, there is no comprehensive summary of the clinical trials related to DPN. In this article, we summarized the basic characteristics of the interventional clinical trials pertaining to DPN to determine the current status of research in this field and the existing issues. MATERIALS AND METHODS: We searched the World Health Organization International Clinical Trial Registration Platform (ICTRP), PubMed and Web of Science for clinical trials from 2005 to April 2021 and extracted 149 registered and 459 published clinical trials on DPN. We summarized the characteristics of the clinical trials, including the source registration, recruitment status, stage, age group, allocation method, intervention, end point classification, funding source, and treatment. RESULTS: After excluding noninterventional and nontreatment trials, 149 registered clinical trials out of 292 records from 12 registration centers and 459 published articles were included in this study. Among the registered trials, 43% had been completed, and 34.4% had been published in peer-reviewed journals. Among these trials, more than half used random allocation and blinded placebo-controlled methodologies. A total of 40.3% of the trials were multicenter studies, 63.8% of the treatments were drug therapies, and the endpoint classifications of 49% were efficacy and safety. Of the 459 published interventional clinical trials on DPN, 69.7% of the trials used drug treatments; more than half were randomized, double-blind, placebo-controlled clinical trials; 94.1% had positive outcomes; 46.4% had a target size of 50; and 22.9% were multicenter. CONCLUSION: This paper systematically summarizes the current status of interventional trials on DPN registered in the ICTRP and published clinical trials and provides a reference for the development of high-quality intervention strategies for DPN in the future. Dove 2021-08-26 /pmc/articles/PMC8405224/ /pubmed/34471381 http://dx.doi.org/10.2147/JPR.S320364 Text en © 2021 Wang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Wang, Mengmeng Zhang, Zepeng Mi, Jia Wang, Guoqiang Tian, Lulu Zhao, Yunyun Li, Xiaomin Li, Xiangyan Wang, Xiuge Interventional Clinical Trials on Diabetic Peripheral Neuropathy: A Retrospective Analysis |
title | Interventional Clinical Trials on Diabetic Peripheral Neuropathy: A Retrospective Analysis |
title_full | Interventional Clinical Trials on Diabetic Peripheral Neuropathy: A Retrospective Analysis |
title_fullStr | Interventional Clinical Trials on Diabetic Peripheral Neuropathy: A Retrospective Analysis |
title_full_unstemmed | Interventional Clinical Trials on Diabetic Peripheral Neuropathy: A Retrospective Analysis |
title_short | Interventional Clinical Trials on Diabetic Peripheral Neuropathy: A Retrospective Analysis |
title_sort | interventional clinical trials on diabetic peripheral neuropathy: a retrospective analysis |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405224/ https://www.ncbi.nlm.nih.gov/pubmed/34471381 http://dx.doi.org/10.2147/JPR.S320364 |
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