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Pharmacokinetics and Pharmacological Activities of Berberine in Diabetes Mellitus Treatment

Traditional Chinese medicine (TCM) has good clinical application prospects in diabetes treatment. In addition, TCM is less toxic and/or has fewer side effects and provides various therapeutic effects. Berberine (BBR) is isolated as the main component in many TCM kinds (e.g., Rhizoma Coptidis and Ber...

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Autores principales: Han, Yunfeng, Xiang, Yunan, Shi, Yi, Tang, Xi, Pan, Lin, Gao, Jie, Bi, Ruohong, Lai, Xianrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405293/
https://www.ncbi.nlm.nih.gov/pubmed/34471420
http://dx.doi.org/10.1155/2021/9987097
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author Han, Yunfeng
Xiang, Yunan
Shi, Yi
Tang, Xi
Pan, Lin
Gao, Jie
Bi, Ruohong
Lai, Xianrong
author_facet Han, Yunfeng
Xiang, Yunan
Shi, Yi
Tang, Xi
Pan, Lin
Gao, Jie
Bi, Ruohong
Lai, Xianrong
author_sort Han, Yunfeng
collection PubMed
description Traditional Chinese medicine (TCM) has good clinical application prospects in diabetes treatment. In addition, TCM is less toxic and/or has fewer side effects and provides various therapeutic effects. Berberine (BBR) is isolated as the main component in many TCM kinds (e.g., Rhizoma Coptidis and Berberidis Cortex). Furthermore, BBR can reduce blood sugar and blood fat, alleviate inflammation, and improve the state of patients. Based on the recent study results of BBR in diabetes treatment, the BBR pharmacokinetics and mechanism on diabetes are mainly studied, and the specific molecular mechanism of related experimental BBR is systematically summarized and analyzed. Clinical studies have proved that BBR has a good therapeutic effect on diabetes, suggesting that BBR may be a promising drug candidate for diabetes. More detailed BBR mechanisms and pathways of BBR need to be studied further in depth, which will help understand the BBR pharmacology in diabetes treatment.
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spelling pubmed-84052932021-08-31 Pharmacokinetics and Pharmacological Activities of Berberine in Diabetes Mellitus Treatment Han, Yunfeng Xiang, Yunan Shi, Yi Tang, Xi Pan, Lin Gao, Jie Bi, Ruohong Lai, Xianrong Evid Based Complement Alternat Med Review Article Traditional Chinese medicine (TCM) has good clinical application prospects in diabetes treatment. In addition, TCM is less toxic and/or has fewer side effects and provides various therapeutic effects. Berberine (BBR) is isolated as the main component in many TCM kinds (e.g., Rhizoma Coptidis and Berberidis Cortex). Furthermore, BBR can reduce blood sugar and blood fat, alleviate inflammation, and improve the state of patients. Based on the recent study results of BBR in diabetes treatment, the BBR pharmacokinetics and mechanism on diabetes are mainly studied, and the specific molecular mechanism of related experimental BBR is systematically summarized and analyzed. Clinical studies have proved that BBR has a good therapeutic effect on diabetes, suggesting that BBR may be a promising drug candidate for diabetes. More detailed BBR mechanisms and pathways of BBR need to be studied further in depth, which will help understand the BBR pharmacology in diabetes treatment. Hindawi 2021-08-21 /pmc/articles/PMC8405293/ /pubmed/34471420 http://dx.doi.org/10.1155/2021/9987097 Text en Copyright © 2021 Yunfeng Han et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Han, Yunfeng
Xiang, Yunan
Shi, Yi
Tang, Xi
Pan, Lin
Gao, Jie
Bi, Ruohong
Lai, Xianrong
Pharmacokinetics and Pharmacological Activities of Berberine in Diabetes Mellitus Treatment
title Pharmacokinetics and Pharmacological Activities of Berberine in Diabetes Mellitus Treatment
title_full Pharmacokinetics and Pharmacological Activities of Berberine in Diabetes Mellitus Treatment
title_fullStr Pharmacokinetics and Pharmacological Activities of Berberine in Diabetes Mellitus Treatment
title_full_unstemmed Pharmacokinetics and Pharmacological Activities of Berberine in Diabetes Mellitus Treatment
title_short Pharmacokinetics and Pharmacological Activities of Berberine in Diabetes Mellitus Treatment
title_sort pharmacokinetics and pharmacological activities of berberine in diabetes mellitus treatment
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405293/
https://www.ncbi.nlm.nih.gov/pubmed/34471420
http://dx.doi.org/10.1155/2021/9987097
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