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Pharmacokinetics and Pharmacological Activities of Berberine in Diabetes Mellitus Treatment
Traditional Chinese medicine (TCM) has good clinical application prospects in diabetes treatment. In addition, TCM is less toxic and/or has fewer side effects and provides various therapeutic effects. Berberine (BBR) is isolated as the main component in many TCM kinds (e.g., Rhizoma Coptidis and Ber...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405293/ https://www.ncbi.nlm.nih.gov/pubmed/34471420 http://dx.doi.org/10.1155/2021/9987097 |
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author | Han, Yunfeng Xiang, Yunan Shi, Yi Tang, Xi Pan, Lin Gao, Jie Bi, Ruohong Lai, Xianrong |
author_facet | Han, Yunfeng Xiang, Yunan Shi, Yi Tang, Xi Pan, Lin Gao, Jie Bi, Ruohong Lai, Xianrong |
author_sort | Han, Yunfeng |
collection | PubMed |
description | Traditional Chinese medicine (TCM) has good clinical application prospects in diabetes treatment. In addition, TCM is less toxic and/or has fewer side effects and provides various therapeutic effects. Berberine (BBR) is isolated as the main component in many TCM kinds (e.g., Rhizoma Coptidis and Berberidis Cortex). Furthermore, BBR can reduce blood sugar and blood fat, alleviate inflammation, and improve the state of patients. Based on the recent study results of BBR in diabetes treatment, the BBR pharmacokinetics and mechanism on diabetes are mainly studied, and the specific molecular mechanism of related experimental BBR is systematically summarized and analyzed. Clinical studies have proved that BBR has a good therapeutic effect on diabetes, suggesting that BBR may be a promising drug candidate for diabetes. More detailed BBR mechanisms and pathways of BBR need to be studied further in depth, which will help understand the BBR pharmacology in diabetes treatment. |
format | Online Article Text |
id | pubmed-8405293 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-84052932021-08-31 Pharmacokinetics and Pharmacological Activities of Berberine in Diabetes Mellitus Treatment Han, Yunfeng Xiang, Yunan Shi, Yi Tang, Xi Pan, Lin Gao, Jie Bi, Ruohong Lai, Xianrong Evid Based Complement Alternat Med Review Article Traditional Chinese medicine (TCM) has good clinical application prospects in diabetes treatment. In addition, TCM is less toxic and/or has fewer side effects and provides various therapeutic effects. Berberine (BBR) is isolated as the main component in many TCM kinds (e.g., Rhizoma Coptidis and Berberidis Cortex). Furthermore, BBR can reduce blood sugar and blood fat, alleviate inflammation, and improve the state of patients. Based on the recent study results of BBR in diabetes treatment, the BBR pharmacokinetics and mechanism on diabetes are mainly studied, and the specific molecular mechanism of related experimental BBR is systematically summarized and analyzed. Clinical studies have proved that BBR has a good therapeutic effect on diabetes, suggesting that BBR may be a promising drug candidate for diabetes. More detailed BBR mechanisms and pathways of BBR need to be studied further in depth, which will help understand the BBR pharmacology in diabetes treatment. Hindawi 2021-08-21 /pmc/articles/PMC8405293/ /pubmed/34471420 http://dx.doi.org/10.1155/2021/9987097 Text en Copyright © 2021 Yunfeng Han et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Han, Yunfeng Xiang, Yunan Shi, Yi Tang, Xi Pan, Lin Gao, Jie Bi, Ruohong Lai, Xianrong Pharmacokinetics and Pharmacological Activities of Berberine in Diabetes Mellitus Treatment |
title | Pharmacokinetics and Pharmacological Activities of Berberine in Diabetes Mellitus Treatment |
title_full | Pharmacokinetics and Pharmacological Activities of Berberine in Diabetes Mellitus Treatment |
title_fullStr | Pharmacokinetics and Pharmacological Activities of Berberine in Diabetes Mellitus Treatment |
title_full_unstemmed | Pharmacokinetics and Pharmacological Activities of Berberine in Diabetes Mellitus Treatment |
title_short | Pharmacokinetics and Pharmacological Activities of Berberine in Diabetes Mellitus Treatment |
title_sort | pharmacokinetics and pharmacological activities of berberine in diabetes mellitus treatment |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405293/ https://www.ncbi.nlm.nih.gov/pubmed/34471420 http://dx.doi.org/10.1155/2021/9987097 |
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