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Exploring the Rare Etiology of Severe Anemia in an Immunocompromised Patient

Pure red cell aplasia (PRCA) is a rare cause of profound anemia, marked by very low reticulocyte count and near to complete absence of erythroid precursor cells in the bone marrow. PRCA can be congenital such as in the case of children with Diamond- Blackfan anemia or acquired, which is often trigge...

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Detalles Bibliográficos
Autores principales: Joseph, Keerthy D, Thota, Vihitha, Bains, Ashish, Patel, Neel S, Mustaqeem, Ruqqiya, Mulla, Sana, Thirumaran, Rajesh, Trawinski, Jakub
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405354/
https://www.ncbi.nlm.nih.gov/pubmed/34513373
http://dx.doi.org/10.7759/cureus.16750
Descripción
Sumario:Pure red cell aplasia (PRCA) is a rare cause of profound anemia, marked by very low reticulocyte count and near to complete absence of erythroid precursor cells in the bone marrow. PRCA can be congenital such as in the case of children with Diamond- Blackfan anemia or acquired, which is often triggered by exposure to certain viruses or drugs. Management depends on the underlying etiology of PRCA. Here, we present the case of a young male with underlying acquired immunodeficiency syndrome, who presented with a hemoglobin of 2.6 g/dL, initially thought to be secondary to gastrointestinal blood loss, but was later discovered to have parvovirus-induced PRCA.