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A latent variable approach to account for correlated inputs in global sensitivity analysis

In drug development decision-making is often supported through model-based methods, such as physiologically-based pharmacokinetics (PBPK). Global sensitivity analysis (GSA) is gaining use for quality assessment of model-informed inference. However, the inclusion and interpretation of correlated fact...

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Detalles Bibliográficos
Autores principales: Melillo, Nicola, Darwich, Adam S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405496/
https://www.ncbi.nlm.nih.gov/pubmed/34032996
http://dx.doi.org/10.1007/s10928-021-09764-x

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