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Impact of the COVID-19 pandemic in patients with systemic lupus erythematosus throughout one year

Little is known about the impact of coronavirus disease 2019 (COVID-19) pandemic to the care of patients with systemic lupus erythematosus (SLE) in the long-term. By crossing population data with the results of a web-based survey focused on the timeframes January–April and May–December 2020, we foun...

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Autores principales: Ramirez, Giuseppe A., Argolini, Lorenza M., Bellocchi, Chiara, Moroni, Luca, Della-Torre, Emanuel, Farina, Nicola, Caporali, Roberto F., Beretta, Lorenzo, Gerosa, Maria, Bozzolo, Enrica P., Dagna, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405598/
https://www.ncbi.nlm.nih.gov/pubmed/34478882
http://dx.doi.org/10.1016/j.clim.2021.108845
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author Ramirez, Giuseppe A.
Argolini, Lorenza M.
Bellocchi, Chiara
Moroni, Luca
Della-Torre, Emanuel
Farina, Nicola
Caporali, Roberto F.
Beretta, Lorenzo
Gerosa, Maria
Bozzolo, Enrica P.
Dagna, Lorenzo
author_facet Ramirez, Giuseppe A.
Argolini, Lorenza M.
Bellocchi, Chiara
Moroni, Luca
Della-Torre, Emanuel
Farina, Nicola
Caporali, Roberto F.
Beretta, Lorenzo
Gerosa, Maria
Bozzolo, Enrica P.
Dagna, Lorenzo
author_sort Ramirez, Giuseppe A.
collection PubMed
description Little is known about the impact of coronavirus disease 2019 (COVID-19) pandemic to the care of patients with systemic lupus erythematosus (SLE) in the long-term. By crossing population data with the results of a web-based survey focused on the timeframes January–April and May–December 2020, we found that among 334/518 responders, 28 had COVID-19 in 2020. Seventeen cases occurred in May–December, in parallel with trends in the general population and loosening of containment policy strength. Age > 40 years (p = 0.026), prednisone escalation (p = 0.008) and infected relatives (p < 0.001) were most significantly associated with COVID-19. Weaker associations were found with asthma, lymphadenopathy and azathioprine or cyclosporine treatment. Only 31% of patients with infected relatives developed COVID-19. Healthcare service disruptions were not associated with rising hospitalisations. Vaccination prospects were generally welcomed. Our data suggest that COVID-19 has a moderate impact on patients with SLE, which might be significantly modulated by public health policies, including vaccination.
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spelling pubmed-84055982021-08-31 Impact of the COVID-19 pandemic in patients with systemic lupus erythematosus throughout one year Ramirez, Giuseppe A. Argolini, Lorenza M. Bellocchi, Chiara Moroni, Luca Della-Torre, Emanuel Farina, Nicola Caporali, Roberto F. Beretta, Lorenzo Gerosa, Maria Bozzolo, Enrica P. Dagna, Lorenzo Clin Immunol Full Length Article Little is known about the impact of coronavirus disease 2019 (COVID-19) pandemic to the care of patients with systemic lupus erythematosus (SLE) in the long-term. By crossing population data with the results of a web-based survey focused on the timeframes January–April and May–December 2020, we found that among 334/518 responders, 28 had COVID-19 in 2020. Seventeen cases occurred in May–December, in parallel with trends in the general population and loosening of containment policy strength. Age > 40 years (p = 0.026), prednisone escalation (p = 0.008) and infected relatives (p < 0.001) were most significantly associated with COVID-19. Weaker associations were found with asthma, lymphadenopathy and azathioprine or cyclosporine treatment. Only 31% of patients with infected relatives developed COVID-19. Healthcare service disruptions were not associated with rising hospitalisations. Vaccination prospects were generally welcomed. Our data suggest that COVID-19 has a moderate impact on patients with SLE, which might be significantly modulated by public health policies, including vaccination. Elsevier Inc. 2021-10 2021-08-31 /pmc/articles/PMC8405598/ /pubmed/34478882 http://dx.doi.org/10.1016/j.clim.2021.108845 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Full Length Article
Ramirez, Giuseppe A.
Argolini, Lorenza M.
Bellocchi, Chiara
Moroni, Luca
Della-Torre, Emanuel
Farina, Nicola
Caporali, Roberto F.
Beretta, Lorenzo
Gerosa, Maria
Bozzolo, Enrica P.
Dagna, Lorenzo
Impact of the COVID-19 pandemic in patients with systemic lupus erythematosus throughout one year
title Impact of the COVID-19 pandemic in patients with systemic lupus erythematosus throughout one year
title_full Impact of the COVID-19 pandemic in patients with systemic lupus erythematosus throughout one year
title_fullStr Impact of the COVID-19 pandemic in patients with systemic lupus erythematosus throughout one year
title_full_unstemmed Impact of the COVID-19 pandemic in patients with systemic lupus erythematosus throughout one year
title_short Impact of the COVID-19 pandemic in patients with systemic lupus erythematosus throughout one year
title_sort impact of the covid-19 pandemic in patients with systemic lupus erythematosus throughout one year
topic Full Length Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405598/
https://www.ncbi.nlm.nih.gov/pubmed/34478882
http://dx.doi.org/10.1016/j.clim.2021.108845
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