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Stepwise low concentration atropine for myopic control: a 10-year cohort study
The aim of this study was to analyze changes in refraction and evaluate the variables in school children who received atropine as myopic control for 10 years. Low-concentration atropine (0.05%) was prescribed initially, and the dose was increased in a stepwise manner if rapid myopic progression (≥ 0...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405709/ https://www.ncbi.nlm.nih.gov/pubmed/34462467 http://dx.doi.org/10.1038/s41598-021-96698-6 |
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author | Chuang, Meng-Ni Fang, Po-Chiung Wu, Pei-Chang |
author_facet | Chuang, Meng-Ni Fang, Po-Chiung Wu, Pei-Chang |
author_sort | Chuang, Meng-Ni |
collection | PubMed |
description | The aim of this study was to analyze changes in refraction and evaluate the variables in school children who received atropine as myopic control for 10 years. Low-concentration atropine (0.05%) was prescribed initially, and the dose was increased in a stepwise manner if rapid myopic progression (≥ 0.5D per half year) was noted during the regular follow-up visit. 23 children with a mean age of 6.96 ± 1.07 years were included. The initial spherical equivalent was − 1.25 ± 0.84 D. The overall mean myopic progression was − 0.30 ± 0.27 D/year. Younger initial age, female, higher initial spherical equivalent and the need of higher concentration of atropine were found to be risk factors for myopic progression in multivariate mixed-effect analysis (p = 0.013, 0.017, 0.024 and 0.014). Children who kept using a lower concentration of atropine (≤ 0.1%) tended to have slower myopic progression throughout the 10-year course than those who shifted to higher concentrations (> 0.1%) (p ≤ 0.001). Stepwise low concentration of atropine might be effective for long-term myopic control in school students. Those who had poor response to lower concentration of atropine may have the risk of faster progression, even with high concentration of atropine. Additional or alternative treatment might be considered. |
format | Online Article Text |
id | pubmed-8405709 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-84057092021-09-01 Stepwise low concentration atropine for myopic control: a 10-year cohort study Chuang, Meng-Ni Fang, Po-Chiung Wu, Pei-Chang Sci Rep Article The aim of this study was to analyze changes in refraction and evaluate the variables in school children who received atropine as myopic control for 10 years. Low-concentration atropine (0.05%) was prescribed initially, and the dose was increased in a stepwise manner if rapid myopic progression (≥ 0.5D per half year) was noted during the regular follow-up visit. 23 children with a mean age of 6.96 ± 1.07 years were included. The initial spherical equivalent was − 1.25 ± 0.84 D. The overall mean myopic progression was − 0.30 ± 0.27 D/year. Younger initial age, female, higher initial spherical equivalent and the need of higher concentration of atropine were found to be risk factors for myopic progression in multivariate mixed-effect analysis (p = 0.013, 0.017, 0.024 and 0.014). Children who kept using a lower concentration of atropine (≤ 0.1%) tended to have slower myopic progression throughout the 10-year course than those who shifted to higher concentrations (> 0.1%) (p ≤ 0.001). Stepwise low concentration of atropine might be effective for long-term myopic control in school students. Those who had poor response to lower concentration of atropine may have the risk of faster progression, even with high concentration of atropine. Additional or alternative treatment might be considered. Nature Publishing Group UK 2021-08-30 /pmc/articles/PMC8405709/ /pubmed/34462467 http://dx.doi.org/10.1038/s41598-021-96698-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Chuang, Meng-Ni Fang, Po-Chiung Wu, Pei-Chang Stepwise low concentration atropine for myopic control: a 10-year cohort study |
title | Stepwise low concentration atropine for myopic control: a 10-year cohort study |
title_full | Stepwise low concentration atropine for myopic control: a 10-year cohort study |
title_fullStr | Stepwise low concentration atropine for myopic control: a 10-year cohort study |
title_full_unstemmed | Stepwise low concentration atropine for myopic control: a 10-year cohort study |
title_short | Stepwise low concentration atropine for myopic control: a 10-year cohort study |
title_sort | stepwise low concentration atropine for myopic control: a 10-year cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405709/ https://www.ncbi.nlm.nih.gov/pubmed/34462467 http://dx.doi.org/10.1038/s41598-021-96698-6 |
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