Durability of antibody response to vaccination and surrogate neutralization of emerging variants based on SARS-CoV-2 exposure history

Two-dose messenger RNA vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are highly effective in preventing symptomatic COVID-19 infection. However, the durability of protection is not known, nor is the effectiveness against emerging viral variants. Additionally, vacc...

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Autores principales: McDade, Thomas W., Demonbreun, Alexis R., Sancilio, Amelia, Mustanski, Brian, D’Aquila, Richard T., McNally, Elizabeth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405730/
https://www.ncbi.nlm.nih.gov/pubmed/34462501
http://dx.doi.org/10.1038/s41598-021-96879-3
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author McDade, Thomas W.
Demonbreun, Alexis R.
Sancilio, Amelia
Mustanski, Brian
D’Aquila, Richard T.
McNally, Elizabeth M.
author_facet McDade, Thomas W.
Demonbreun, Alexis R.
Sancilio, Amelia
Mustanski, Brian
D’Aquila, Richard T.
McNally, Elizabeth M.
author_sort McDade, Thomas W.
collection PubMed
description Two-dose messenger RNA vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are highly effective in preventing symptomatic COVID-19 infection. However, the durability of protection is not known, nor is the effectiveness against emerging viral variants. Additionally, vaccine responses may differ based on prior SARS-CoV-2 exposure history. To investigate protection against SARS-CoV-2 variants we measured binding and neutralizing antibody responses following both vaccine doses. We document significant declines in antibody levels three months post-vaccination, and reduced neutralization of emerging variants, highlighting the need to identify correlates of clinical protection to inform the timing of and indications for booster vaccination.
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spelling pubmed-84057302021-09-01 Durability of antibody response to vaccination and surrogate neutralization of emerging variants based on SARS-CoV-2 exposure history McDade, Thomas W. Demonbreun, Alexis R. Sancilio, Amelia Mustanski, Brian D’Aquila, Richard T. McNally, Elizabeth M. Sci Rep Article Two-dose messenger RNA vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are highly effective in preventing symptomatic COVID-19 infection. However, the durability of protection is not known, nor is the effectiveness against emerging viral variants. Additionally, vaccine responses may differ based on prior SARS-CoV-2 exposure history. To investigate protection against SARS-CoV-2 variants we measured binding and neutralizing antibody responses following both vaccine doses. We document significant declines in antibody levels three months post-vaccination, and reduced neutralization of emerging variants, highlighting the need to identify correlates of clinical protection to inform the timing of and indications for booster vaccination. Nature Publishing Group UK 2021-08-30 /pmc/articles/PMC8405730/ /pubmed/34462501 http://dx.doi.org/10.1038/s41598-021-96879-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
McDade, Thomas W.
Demonbreun, Alexis R.
Sancilio, Amelia
Mustanski, Brian
D’Aquila, Richard T.
McNally, Elizabeth M.
Durability of antibody response to vaccination and surrogate neutralization of emerging variants based on SARS-CoV-2 exposure history
title Durability of antibody response to vaccination and surrogate neutralization of emerging variants based on SARS-CoV-2 exposure history
title_full Durability of antibody response to vaccination and surrogate neutralization of emerging variants based on SARS-CoV-2 exposure history
title_fullStr Durability of antibody response to vaccination and surrogate neutralization of emerging variants based on SARS-CoV-2 exposure history
title_full_unstemmed Durability of antibody response to vaccination and surrogate neutralization of emerging variants based on SARS-CoV-2 exposure history
title_short Durability of antibody response to vaccination and surrogate neutralization of emerging variants based on SARS-CoV-2 exposure history
title_sort durability of antibody response to vaccination and surrogate neutralization of emerging variants based on sars-cov-2 exposure history
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405730/
https://www.ncbi.nlm.nih.gov/pubmed/34462501
http://dx.doi.org/10.1038/s41598-021-96879-3
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