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Psychological stress and health-related quality of life among tuberculosis patients: a prospective cohort study

Economic, social and psychological distress is common in individuals affected by tuberculosis (TB). However, the magnitude of distress, psychological interventions and their effect on the treatment outcomes are often under-evaluated. We examined the level of psychological stress and health-related q...

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Autores principales: Febi, Ann Roy, Manu, Mohan K., Mohapatra, Aswini Kumar, Praharaj, Samir Kumar, Guddattu, Vasudeva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405877/
https://www.ncbi.nlm.nih.gov/pubmed/34476253
http://dx.doi.org/10.1183/23120541.00251-2021
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author Febi, Ann Roy
Manu, Mohan K.
Mohapatra, Aswini Kumar
Praharaj, Samir Kumar
Guddattu, Vasudeva
author_facet Febi, Ann Roy
Manu, Mohan K.
Mohapatra, Aswini Kumar
Praharaj, Samir Kumar
Guddattu, Vasudeva
author_sort Febi, Ann Roy
collection PubMed
description Economic, social and psychological distress is common in individuals affected by tuberculosis (TB). However, the magnitude of distress, psychological interventions and their effect on the treatment outcomes are often under-evaluated. We examined the level of psychological stress and health-related quality of life (HRQoL) of such patients and the effect of antituberculosis therapy on them.  Our prospective cohort study included newly diagnosed adult pulmonary and extrapulmonary TB patients. Assessment of psychological stress was done using the seven-item Generalised Anxiety Disorder questionnaire for anxiety and the nine-item Patient Health Questionnaire for depression. HRQoL was assessed by using the WHOQOL-BREF questionnaire.  Of the 86 patients studied, 21 (24.4%) had anxiety symptoms at the baseline, which reduced to 5.8% and 1.2% at 2 months and treatment completion, respectively (p<0.001). Among the subjects, 18 (20.9%) patients had depression, which reduced to 7% and 2.3% at 2 months and treatment completion, respectively (p<0.001). All the mean domain scores of HRQoL were poor at the baseline, which showed improvement at treatment completion (p<0.001).  Anxiety and depression were common among TB patients, and there was significant progressive reduction during and after treatment. TB had remarkable negative impacts on HRQoL, with the physical domain being the most affected, and all the domain scores showed significant improvement at treatment completion. Routine screening for depression and anxiety and timely referral to a psychiatrist are required in TB patients to improve the outcome of the disease and quality of life.
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spelling pubmed-84058772021-09-01 Psychological stress and health-related quality of life among tuberculosis patients: a prospective cohort study Febi, Ann Roy Manu, Mohan K. Mohapatra, Aswini Kumar Praharaj, Samir Kumar Guddattu, Vasudeva ERJ Open Res Original Research Articles Economic, social and psychological distress is common in individuals affected by tuberculosis (TB). However, the magnitude of distress, psychological interventions and their effect on the treatment outcomes are often under-evaluated. We examined the level of psychological stress and health-related quality of life (HRQoL) of such patients and the effect of antituberculosis therapy on them.  Our prospective cohort study included newly diagnosed adult pulmonary and extrapulmonary TB patients. Assessment of psychological stress was done using the seven-item Generalised Anxiety Disorder questionnaire for anxiety and the nine-item Patient Health Questionnaire for depression. HRQoL was assessed by using the WHOQOL-BREF questionnaire.  Of the 86 patients studied, 21 (24.4%) had anxiety symptoms at the baseline, which reduced to 5.8% and 1.2% at 2 months and treatment completion, respectively (p<0.001). Among the subjects, 18 (20.9%) patients had depression, which reduced to 7% and 2.3% at 2 months and treatment completion, respectively (p<0.001). All the mean domain scores of HRQoL were poor at the baseline, which showed improvement at treatment completion (p<0.001).  Anxiety and depression were common among TB patients, and there was significant progressive reduction during and after treatment. TB had remarkable negative impacts on HRQoL, with the physical domain being the most affected, and all the domain scores showed significant improvement at treatment completion. Routine screening for depression and anxiety and timely referral to a psychiatrist are required in TB patients to improve the outcome of the disease and quality of life. European Respiratory Society 2021-08-31 /pmc/articles/PMC8405877/ /pubmed/34476253 http://dx.doi.org/10.1183/23120541.00251-2021 Text en Copyright ©The authors 2021 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org)
spellingShingle Original Research Articles
Febi, Ann Roy
Manu, Mohan K.
Mohapatra, Aswini Kumar
Praharaj, Samir Kumar
Guddattu, Vasudeva
Psychological stress and health-related quality of life among tuberculosis patients: a prospective cohort study
title Psychological stress and health-related quality of life among tuberculosis patients: a prospective cohort study
title_full Psychological stress and health-related quality of life among tuberculosis patients: a prospective cohort study
title_fullStr Psychological stress and health-related quality of life among tuberculosis patients: a prospective cohort study
title_full_unstemmed Psychological stress and health-related quality of life among tuberculosis patients: a prospective cohort study
title_short Psychological stress and health-related quality of life among tuberculosis patients: a prospective cohort study
title_sort psychological stress and health-related quality of life among tuberculosis patients: a prospective cohort study
topic Original Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405877/
https://www.ncbi.nlm.nih.gov/pubmed/34476253
http://dx.doi.org/10.1183/23120541.00251-2021
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