Epistatic interactions promote persistence of NS3-Q80K in HCV infection by compensating for protein folding instability

The Q80K polymorphism in the NS3-4A protease of the hepatitis C virus is associated with treatment failure of direct-acting antiviral agents. This polymorphism is highly prevalent in genotype 1a infections and stably transmitted between hosts. Here, we investigated the underlying molecular mechanism...

Descripción completa

Detalles Bibliográficos
Autores principales: Dultz, Georg, Srikakulam, Sanjay K., Konetschnik, Michael, Shimakami, Tetsuro, Doncheva, Nadezhda T., Dietz, Julia, Sarrazin, Christoph, Biondi, Ricardo M., Zeuzem, Stefan, Tampé, Robert, Kalinina, Olga V., Welsch, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405986/
https://www.ncbi.nlm.nih.gov/pubmed/34339738
http://dx.doi.org/10.1016/j.jbc.2021.101031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405986/
https://www.ncbi.nlm.nih.gov/pubmed/34339738
http://dx.doi.org/10.1016/j.jbc.2021.101031

Ejemplares similares