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Epistatic interactions promote persistence of NS3-Q80K in HCV infection by compensating for protein folding instability

The Q80K polymorphism in the NS3-4A protease of the hepatitis C virus is associated with treatment failure of direct-acting antiviral agents. This polymorphism is highly prevalent in genotype 1a infections and stably transmitted between hosts. Here, we investigated the underlying molecular mechanism...

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Detalles Bibliográficos
Autores principales:	Dultz, Georg, Srikakulam, Sanjay K., Konetschnik, Michael, Shimakami, Tetsuro, Doncheva, Nadezhda T., Dietz, Julia, Sarrazin, Christoph, Biondi, Ricardo M., Zeuzem, Stefan, Tampé, Robert, Kalinina, Olga V., Welsch, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405986/ https://www.ncbi.nlm.nih.gov/pubmed/34339738 http://dx.doi.org/10.1016/j.jbc.2021.101031

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