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A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase

The macrophage migration inhibitory factor (MIF) family of cytokines contains multiple ligand-binding sites and mediates immunomodulatory processes through an undefined mechanism(s). Previously, we reported a dynamic relay connecting the MIF catalytic site to an allosteric site at its solvent channe...

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Detalles Bibliográficos
Autores principales:	Chen, Emily, Reiss, Krystle, Shah, Dilip, Manjula, Ramu, Allen, Brandon, Murphy, Eva L., Murphy, James W., Batista, Victor S., Bhandari, Vineet, Lolis, Elias J., Lisi, George P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405996/ https://www.ncbi.nlm.nih.gov/pubmed/34384784 http://dx.doi.org/10.1016/j.jbc.2021.101061

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