Disease-associated mutations impacting BC-loop flexibility trigger long-range transthyretin tetramer destabilization and aggregation

Hereditary transthyretin amyloidosis (ATTR) is an autosomal dominant disease characterized by the extracellular deposition of the transport protein transthyretin (TTR) as amyloid fibrils. Despite the progress achieved in recent years, understanding why different TTR residue substitutions lead to dif...

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Detalles Bibliográficos
Autores principales: Esperante, Sebastián A., Varejāo, Nathalia, Pinheiro, Francisca, Sant'Anna, Ricardo, Luque-Ortega, Juan Román, Alfonso, Carlos, Sora, Valentina, Papaleo, Elena, Rivas, Germán, Reverter, David, Ventura, Salvador
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406001/
https://www.ncbi.nlm.nih.gov/pubmed/34343569
http://dx.doi.org/10.1016/j.jbc.2021.101039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406001/
https://www.ncbi.nlm.nih.gov/pubmed/34343569
http://dx.doi.org/10.1016/j.jbc.2021.101039

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