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The m(6)A methyltransferase METTL3 modifies PGC-1α mRNA promoting mitochondrial dysfunction and oxLDL-induced inflammation in monocytes

Mitochondrial biogenesis and energy metabolism are essential for regulating the inflammatory state of monocytes. This state is partially controlled by peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), a coactivator that regulates mitochondrial biogenesis and energy metab...

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Detalles Bibliográficos
Autores principales:	Zhang, Xinning, Li, Xin, Jia, Hongti, An, Guoshun, Ni, Juhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406003/ https://www.ncbi.nlm.nih.gov/pubmed/34375639 http://dx.doi.org/10.1016/j.jbc.2021.101058

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