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Cardioprotective effect of MLN4924 on ameliorating autophagic flux impairment in myocardial ischemia-reperfusion injury by Sirt1

Neddylation is essential for cardiomyocyte survival in the presence of oxidative stress, and it participates in autophagy regulation. However, whether MLN4924—an inhibitor of neddylation—exerts cardioprotective effects against myocardial ischemia/reperfusion (MI/R) remains unknown. In the present st...

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Detalles Bibliográficos
Autores principales:	Zhang, Ji, Cui, Jing, Zhao, Fei, Yang, Longhua, Xu, Xueli, Shi, Yangyang, Wei, Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406034/ https://www.ncbi.nlm.nih.gov/pubmed/34454165 http://dx.doi.org/10.1016/j.redox.2021.102114

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