Cargando…

Enzymatic Production of 3-OH Phlorizin, a Possible Bioactive Polyphenol from Apples, by Bacillus megaterium CYP102A1 via Regioselective Hydroxylation

Phlorizin is the most abundant glucoside of phloretin from the apple tree and its products. Phlorizin and its aglycone phloretin are currently considered health-beneficial polyphenols from apples useful in treating hyperglycemia and obesity. Recently, we showed that phloretin could be regioselective...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nguyen, Ngoc Anh, Cao, Ngoc Tan, Nguyen, Thi Huong Ha, Ji, Jung-Hwan, Cha, Gun Su, Kang, Hyung-Sik, Yun, Chul-Ho
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406095/ https://www.ncbi.nlm.nih.gov/pubmed/34439575 http://dx.doi.org/10.3390/antiox10081327

Ejemplares similares

A Novel Statin Compound from Monacolin J Produced Using CYP102A1-Catalyzed Regioselective C-Hydroxylation
por: Cao, Ngoc Tan, et al.
Publicado: (2021)

Regioselective Hydroxylation of Phloretin, a Bioactive Compound from Apples, by Human Cytochrome P450 Enzymes
por: Nguyen, Ngoc Anh, et al.
Publicado: (2020)

Characterization of diverse natural variants of CYP102A1 found within a species of Bacillus megaterium
por: Kang, Ji-Yeon, et al.
Publicado: (2011)

CYP154C5 Regioselectivity in Steroid Hydroxylation Explored by Substrate Modifications and Protein Engineering
por: Bracco, Paula, et al.
Publicado: (2020)

Whole cells of recombinant CYP153A6-E. coli as biocatalyst for regioselective hydroxylation of monoterpenes
por: Cannazza, Pietro, et al.
Publicado: (2022)

Optimization of Phlorizin Extraction from Annurca Apple Tree Leaves Using Response Surface Methodology
por: Maisto, Maria, et al.
Publicado: (2022)

Monooxygenase-catalyzed regioselective hydroxylation for the synthesis of hydroxyequols
por: Hashimoto, Takafumi, et al.
Publicado: (2019)

The Phlorizin-Degrading Bacillus licheniformis XNRB-3 Mediates Soil Microorganisms to Alleviate Apple Replant Disease
por: Duan, Yanan, et al.
Publicado: (2022)

Bifunctional CYP81AA proteins catalyse identical hydroxylations but alternative regioselective phenol couplings in plant xanthone biosynthesis
por: El-Awaad, Islam, et al.
Publicado: (2016)

Computational redesign of cytochrome P450 CYP102A1 for highly stereoselective omeprazole hydroxylation by UniDesign
por: Huang, Xiaoqiang, et al.
Publicado: (2023)

Role of residue 87 in substrate selectivity and regioselectivity of drug-metabolizing cytochrome P450 CYP102A1 M11
por: Vottero, Eduardo, et al.
Publicado: (2011)

Regioselective Protection of the 4-Hydroxyl of 3,4-Dihydroxy-benzaldehyde
por: Plourde, Guy L., et al.
Publicado: (2002)

Taming the Reactivity of Monoterpene Synthases To Guide Regioselective Product Hydroxylation
por: Leferink, Nicole G. H., et al.
Publicado: (2019)

Steroids hydroxylation catalyzed by the monooxygenase mutant 139-3 from Bacillus megaterium BM3
por: Liu, Xing, et al.
Publicado: (2017)

Enzymatic Activities of CYP3A4 Allelic Variants on Quinine 3-Hydroxylation In Vitro
por: Zhou, Xiao-Yang, et al.
Publicado: (2019)

Phlorizin Prevents Glomerular Hyperfiltration but not Hypertrophy in Diabetic Rats
por: Malatiali, Slava, et al.
Publicado: (2008)

ULTRASTRUCTURE OF ISOLATED KIDNEY MITOCHONDRIA TREATED WITH PHLORIZIN AND ATP
por: Burgos, Mario H., et al.
Publicado: (1964)

Purified Phlorizin from DocynIa Indica (Wall.) Decne by HSCCC, Compared with Whole Extract, Phlorizin and Non-Phlorizin Fragment Ameliorate Obesity, Insulin Resistance, and Improves Intestinal Barrier Function in High-Fat-Diet-Fed Mice
por: Zhang, Xiao-yu, et al.
Publicado: (2018)

Regioselective Enzymatic Carboxylation of Phenols and Hydroxystyrene Derivatives
por: Wuensch, Christiane, et al.
Publicado: (2012)

Regioselective Enzymatic Carboxylation of Bioactive (Poly)phenols
por: Plasch, Katharina, et al.
Publicado: (2017)

Smart regioselectivity towards mono 6-hydroxyl α-cyclodextrin amphiphilic derivatives
por: Cui, Yanli, et al.
Publicado: (2020)

Effects of phlorizin and acipimox on insulin resistance in STZ-diabetic rats.
por: Kim, Y. W., et al.
Publicado: (1995)

Characterization of Two Self-Sufficient Monooxygenases, CYP102A15 and CYP102A170, as Long-Chain Fatty Acid Hydroxylases
por: Rimal, Hemraj, et al.
Publicado: (2020)

A Simple, Effective, Green Method for the Regioselective 3-Acylation of Unprotected Indoles
por: Tran, Phuong Hoang, et al.
Publicado: (2015)

Hydroxylated Derivatives of NPC1161: Theoretical Insights into Their Potential Toxicity and the Feasibility and Regioselectivity of Their Formation
por: Ding, Yuanqing, et al.
Publicado: (2014)

HIGH-RESOLUTION RADIOAUTOGRAPHY OF PHLORIZIN-(3)H IN RINGS OF HAMSTER INTESTINE
por: Stirling, Charles E.
Publicado: (1967)

A novel single-point mutation of NEFH and biallelic SACS mutation presenting as intermediate form Charcot-Marie-Tooth: A case report in Vietnam
por: Truong, Anh Tuan, et al.
Publicado: (2022)

Case report: the first case of human infection by adult of SPIROMETRA ERINACEIEUROPAEI in VIETNAM
por: Le, Anh Tran, et al.
Publicado: (2017)

Effects of salbutamol and phlorizin on acute pulmonary inflammation and disease severity in experimental sepsis
por: Cardoso-Sousa, Léia, et al.
Publicado: (2019)

Metabolomics Insights of the Immunomodulatory Activities of Phlorizin and Phloretin on Human THP-1 Macrophages
por: Cambeiro-Pérez, Noelia, et al.
Publicado: (2021)

Hypoglycemic and hypolipidemic activities of phlorizin from Lithocarpus polystachyus Rehd in diabetes rats
por: Zhang, Wei, et al.
Publicado: (2021)

Enzymatic Hydroxylation and Excision of Extended 5-Methylcytosine Analogues
por: Tomkuvienė, Miglė, et al.
Publicado: (2020)

Directing Group-Controlled Regioselectivity in an Enzymatic C–H Bond Oxygenation
por: Negretti, Solymar, et al.
Publicado: (2014)

Draft Genome Sequence of the Bacterial Endophyte Priestia megaterium B1, Isolated from Roots of Apple (Malus domestica)
por: Mahmoud, Fatma M., et al.
Publicado: (2023)

3-OH Phloretin Inhibits High-Fat Diet-Induced Obesity and Obesity-Induced Inflammation by Reducing Macrophage Infiltration into White Adipose Tissue
por: Woo, Su-Min, et al.
Publicado: (2023)

Investigation of the Protective Effects of Phlorizin on Diabetic Cardiomyopathy in db/db Mice by Quantitative Proteomics
por: Cai, Qian, et al.
Publicado: (2013)

Structural basis of steroid binding and oxidation by the cytochrome P450 CYP109E1 from Bacillus megaterium
por: Jóźwik, Ilona K., et al.
Publicado: (2016)

A case of Wilson disease with the ATP7B mutation presenting movement disorders
por: Van Nguyen, Huong, et al.
Publicado: (2021)

Highly Efficient and Enzymatic Regioselective Undecylenoylation of Gastrodin in 2-Methyltetrahydrofuran-Containing Systems
por: Yang, Rongling, et al.
Publicado: (2014)

Evolution of Ubiquinone Biosynthesis: Multiple Proteobacterial Enzymes with Various Regioselectivities To Catalyze Three Contiguous Aromatic Hydroxylation Reactions
por: Pelosi, Ludovic, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_9c4rdpmu5qkijl91n7prh8m013