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Absence of CD28-CTLA4-PD-L1 Costimulatory Molecules Reduces Herpes Simplex Virus 1 Reactivation

We previously reported that herpes simplex virus 1 (HSV-1) ICP22 binds to CD80 and suppresses CD80 expression in vitro and in vivo. Similar to ICP22, the cellular costimulatory molecules CD28, CTLA4, and PD-L1 also bind to CD80. In this study, we asked whether, similar to ICP22-null virus, the absen...

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Detalles Bibliográficos
Autores principales:	Matundan, Harry H., Jaggi, Ujjaldeep, Yu, Jack, Akbari, Omid, Ghiasi, Homayon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406230/ https://www.ncbi.nlm.nih.gov/pubmed/34281386 http://dx.doi.org/10.1128/mBio.01176-21

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