Persister Escherichia coli Cells Have a Lower Intracellular pH than Susceptible Cells but Maintain Their pH in Response to Antibiotic Treatment

Persister and viable but non-culturable (VBNC) cells are two clonal subpopulations that can survive multidrug exposure via a plethora of putative molecular mechanisms. Here, we combine microfluidics, time-lapse microscopy, and a plasmid-encoded fluorescent pH reporter to measure the dynamics of the...

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Detalles Bibliográficos
Autores principales: Goode, Olivia, Smith, Ashley, Zarkan, Ashraf, Cama, Jehangir, Invergo, Brandon M., Belgami, Daaniyah, Caño-Muñiz, Santiago, Metz, Jeremy, O’Neill, Paul, Jeffries, Aaron, Norville, Isobel H., David, Jonathan, Summers, David, Pagliara, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406257/
https://www.ncbi.nlm.nih.gov/pubmed/34281389
http://dx.doi.org/10.1128/mBio.00909-21

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