Near-Pan-neutralizing, Plasma Deconvoluted Antibody N49P6 Mimics Host Receptor CD4 in Its Quaternary Interactions with the HIV-1 Envelope Trimer

The first step in HIV-1 entry is the attachment of the envelope (Env) trimer to target cell CD4. As such, the CD4-binding site (CD4bs) remains one of the few universally accessible sites for antibodies (Abs). We recently described a method of isolating Abs directly from the circulating plasma and de...

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Detalles Bibliográficos
Autores principales: Tolbert, William D., Nguyen, Dung N., Tehrani, Zahra Rikhtegaran, Sajadi, Mohammad M., Pazgier, Marzena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406290/
https://www.ncbi.nlm.nih.gov/pubmed/34281393
http://dx.doi.org/10.1128/mBio.01274-21

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