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Cellular 5′-3′ mRNA Exoribonuclease XRN1 Inhibits Interferon Beta Activation and Facilitates Influenza A Virus Replication

Cellular 5′-3′ exoribonuclease 1 (XRN1) is best known for its role as a decay factor, which by degrading 5′ monophosphate RNA after the decapping of DCP2 in P-bodies (PBs) in Drosophila, yeast, and mammals. XRN1 has been shown to degrade host antiviral mRNAs following the influenza A virus (IAV) PA-...

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Detalles Bibliográficos
Autores principales:	Liu, Yen-Chin, Mok, Bobo Wing-Yee, Wang, Pui, Kuo, Rei-Lin, Chen, Honglin, Shih, Shin-Ru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406323/ https://www.ncbi.nlm.nih.gov/pubmed/34311580 http://dx.doi.org/10.1128/mBio.00945-21

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