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Specificity and Mechanism of Coronavirus, Rotavirus, and Mammalian Two-Histidine Phosphoesterases That Antagonize Antiviral Innate Immunity

The 2′,5′-oligoadenylate (2-5A)-dependent endoribonuclease, RNase L, is a principal mediator of the interferon (IFN) antiviral response. Therefore, the regulation of cellular levels of 2-5A is a key point of control in antiviral innate immunity. Cellular 2-5A levels are determined by IFN-inducible 2...

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Detalles Bibliográficos
Autores principales:	Asthana, Abhishek, Gaughan, Christina, Dong, Beihua, Weiss, Susan R., Silverman, Robert H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406329/ https://www.ncbi.nlm.nih.gov/pubmed/34372695 http://dx.doi.org/10.1128/mBio.01781-21

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