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The role of single nucleotide polymorphisms of IL-1A -889C>T (rs1800587), TNF-A -238G>A (rs361525), and VDR TaqI (rs731236) on susceptibility to herniated nucleus pulposus: a systematic review and meta-analysis
Background: The pathogenesis of herniated nucleus pulposus (HNP) is complex and may involve the wide variety of gene polymorphism. However, the reports from the existing studies are inconclusive. The objective of this study was to determine the role of single nucleotide polymorphisms (SNPs) in inter...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000 Research Limited
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406444/ https://www.ncbi.nlm.nih.gov/pubmed/34504685 http://dx.doi.org/10.12688/f1000research.53235.3 |
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author | Azharuddin, Azharuddin Ilmawan, Muhammad Fajar, Jonny Karunia Fahriani, Marhami Mamada, Sukamto S. Maliga, Helnida Anggun Nainu, Firzan Dhama, Kuldeep Harapan, Harapan Magetsari, Rahadyan |
author_facet | Azharuddin, Azharuddin Ilmawan, Muhammad Fajar, Jonny Karunia Fahriani, Marhami Mamada, Sukamto S. Maliga, Helnida Anggun Nainu, Firzan Dhama, Kuldeep Harapan, Harapan Magetsari, Rahadyan |
author_sort | Azharuddin, Azharuddin |
collection | PubMed |
description | Background: The pathogenesis of herniated nucleus pulposus (HNP) is complex and may involve the wide variety of gene polymorphism. However, the reports from the existing studies are inconclusive. The objective of this study was to determine the role of single nucleotide polymorphisms (SNPs) in interleukin 1 alpha ( IL-1A), tumor necrosis factor-alpha ( TNF-A), and vitamin D receptor ( VDR) genes on the susceptibility to herniated nucleus pulposus (HNP). Methods: Four databases (PubMed, Embase, Cochrane, and Web of Science) were searched as of April 1 (st), 2021. Authors, publication year, targeted genes, genotype and allele frequency in each case and control groups were collected. Newcastle-Ottawa scale was used to evaluate the publication quality. The pooled estimates of association of IL-1A -889C>T (rs1800587), TNF-A -238G>A (rs361525), and VDR TaqI (rs731236) and susceptibility to HNP were assessed using Z test. Results: We screened 3,067 unique studies for eligibility and three, two and nine case-control studies on IL-1A -889C>T, TNF-A -238G>A, and VDR TaqI were included, respectively, in our meta-analysis. The studies consisting 369 HNP cases and 433 controls for IL-1A -889C>T, 252 cases and 259 controls for TNF-A -238G>A and 1130 cases and 2096 controls for VDR TaqI. Our pooled estimates indicated that there was no significant association of those SNPs with the susceptibility to HNP in any genotype, dominant model, recessive model, or allele comparations. Conclusion: Although individual studies suggested the important role of gene expression dysregulation associated with SNPs in IL-1A, TNF-A, and VDR, our data indicated that IL-1A -889C>T, TNF-A -238G>A, and VDR TaqI had weak association with HNP susceptibility in both genotypes and allele distributions. However, since heterogeneity was identified among studies included in this meta-analysis, further meta-analysis with a larger population and subgroup analysis on specific population are warranted to support this finding. |
format | Online Article Text |
id | pubmed-8406444 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | F1000 Research Limited |
record_format | MEDLINE/PubMed |
spelling | pubmed-84064442021-09-08 The role of single nucleotide polymorphisms of IL-1A -889C>T (rs1800587), TNF-A -238G>A (rs361525), and VDR TaqI (rs731236) on susceptibility to herniated nucleus pulposus: a systematic review and meta-analysis Azharuddin, Azharuddin Ilmawan, Muhammad Fajar, Jonny Karunia Fahriani, Marhami Mamada, Sukamto S. Maliga, Helnida Anggun Nainu, Firzan Dhama, Kuldeep Harapan, Harapan Magetsari, Rahadyan F1000Res Systematic Review Background: The pathogenesis of herniated nucleus pulposus (HNP) is complex and may involve the wide variety of gene polymorphism. However, the reports from the existing studies are inconclusive. The objective of this study was to determine the role of single nucleotide polymorphisms (SNPs) in interleukin 1 alpha ( IL-1A), tumor necrosis factor-alpha ( TNF-A), and vitamin D receptor ( VDR) genes on the susceptibility to herniated nucleus pulposus (HNP). Methods: Four databases (PubMed, Embase, Cochrane, and Web of Science) were searched as of April 1 (st), 2021. Authors, publication year, targeted genes, genotype and allele frequency in each case and control groups were collected. Newcastle-Ottawa scale was used to evaluate the publication quality. The pooled estimates of association of IL-1A -889C>T (rs1800587), TNF-A -238G>A (rs361525), and VDR TaqI (rs731236) and susceptibility to HNP were assessed using Z test. Results: We screened 3,067 unique studies for eligibility and three, two and nine case-control studies on IL-1A -889C>T, TNF-A -238G>A, and VDR TaqI were included, respectively, in our meta-analysis. The studies consisting 369 HNP cases and 433 controls for IL-1A -889C>T, 252 cases and 259 controls for TNF-A -238G>A and 1130 cases and 2096 controls for VDR TaqI. Our pooled estimates indicated that there was no significant association of those SNPs with the susceptibility to HNP in any genotype, dominant model, recessive model, or allele comparations. Conclusion: Although individual studies suggested the important role of gene expression dysregulation associated with SNPs in IL-1A, TNF-A, and VDR, our data indicated that IL-1A -889C>T, TNF-A -238G>A, and VDR TaqI had weak association with HNP susceptibility in both genotypes and allele distributions. However, since heterogeneity was identified among studies included in this meta-analysis, further meta-analysis with a larger population and subgroup analysis on specific population are warranted to support this finding. F1000 Research Limited 2021-08-23 /pmc/articles/PMC8406444/ /pubmed/34504685 http://dx.doi.org/10.12688/f1000research.53235.3 Text en Copyright: © 2021 Azharuddin A et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Systematic Review Azharuddin, Azharuddin Ilmawan, Muhammad Fajar, Jonny Karunia Fahriani, Marhami Mamada, Sukamto S. Maliga, Helnida Anggun Nainu, Firzan Dhama, Kuldeep Harapan, Harapan Magetsari, Rahadyan The role of single nucleotide polymorphisms of IL-1A -889C>T (rs1800587), TNF-A -238G>A (rs361525), and VDR TaqI (rs731236) on susceptibility to herniated nucleus pulposus: a systematic review and meta-analysis |
title | The role of single nucleotide polymorphisms of
IL-1A -889C>T (rs1800587),
TNF-A -238G>A (rs361525), and
VDR TaqI (rs731236) on susceptibility to herniated nucleus pulposus: a systematic review and meta-analysis |
title_full | The role of single nucleotide polymorphisms of
IL-1A -889C>T (rs1800587),
TNF-A -238G>A (rs361525), and
VDR TaqI (rs731236) on susceptibility to herniated nucleus pulposus: a systematic review and meta-analysis |
title_fullStr | The role of single nucleotide polymorphisms of
IL-1A -889C>T (rs1800587),
TNF-A -238G>A (rs361525), and
VDR TaqI (rs731236) on susceptibility to herniated nucleus pulposus: a systematic review and meta-analysis |
title_full_unstemmed | The role of single nucleotide polymorphisms of
IL-1A -889C>T (rs1800587),
TNF-A -238G>A (rs361525), and
VDR TaqI (rs731236) on susceptibility to herniated nucleus pulposus: a systematic review and meta-analysis |
title_short | The role of single nucleotide polymorphisms of
IL-1A -889C>T (rs1800587),
TNF-A -238G>A (rs361525), and
VDR TaqI (rs731236) on susceptibility to herniated nucleus pulposus: a systematic review and meta-analysis |
title_sort | role of single nucleotide polymorphisms of
il-1a -889c>t (rs1800587),
tnf-a -238g>a (rs361525), and
vdr taqi (rs731236) on susceptibility to herniated nucleus pulposus: a systematic review and meta-analysis |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406444/ https://www.ncbi.nlm.nih.gov/pubmed/34504685 http://dx.doi.org/10.12688/f1000research.53235.3 |
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