Mechanical activation of spike fosters SARS-CoV-2 viral infection

The outbreak of SARS-CoV-2 (SARS2) has caused a global COVID-19 pandemic. The spike protein of SARS2 (SARS2-S) recognizes host receptors, including ACE2, to initiate viral entry in a complex biomechanical environment. Here, we reveal that tensile force, generated by bending of the host cell membrane...

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Detalles Bibliográficos
Autores principales: Hu, Wei, Zhang, Yong, Fei, Panyu, Zhang, Tongtong, Yao, Danmei, Gao, Yufei, Liu, Jia, Chen, Hui, Lu, Qiao, Mudianto, Tenny, Zhang, Xinrui, Xiao, Chuxuan, Ye, Yang, Sun, Qiming, Zhang, Jing, Xie, Qi, Wang, Pei-Hui, Wang, Jun, Li, Zhenhai, Lou, Jizhong, Chen, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406658/
https://www.ncbi.nlm.nih.gov/pubmed/34465913
http://dx.doi.org/10.1038/s41422-021-00558-x

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