Cargando…

The m6A Methyltransferase METTL14-Mediated N6-Methyladenosine Modification of PTEN mRNA Inhibits Tumor Growth and Metastasis in Stomach Adenocarcinoma

BACKGROUND: Stomach adenocarcinoma (STAD) is a common reason for tumor-related fatalities globally, as it results in distant metastasis. Methyltransferase-like 14 (METTL14), a notable RNA N6-adenosine methyltransferase (m6A), plays a significant role in the growth of tumor through controlling the RN...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yao, Qi, He, Lanzhen, Gao, Xucan, Tang, Na, Lin, Lifen, Yu, Xiaofang, Wang, Dong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406853/ https://www.ncbi.nlm.nih.gov/pubmed/34476213 http://dx.doi.org/10.3389/fonc.2021.699749

Ejemplares similares

METTL3 regulates N6-methyladenosine modification of ANGPTL3 mRNA and potentiates malignant progression of stomach adenocarcinoma
por: Zhang, Zhijin, et al.
Publicado: (2023)

The m6A Methyltransferase METTL3-Mediated N6-Methyladenosine Modification of DEK mRNA to Promote Gastric Cancer Cell Growth and Metastasis
por: Zhang, Hui-Min, et al.
Publicado: (2022)

Solution structure of the RNA recognition domain of METTL3-METTL14 N(6)-methyladenosine methyltransferase
por: Huang, Jinbo, et al.
Publicado: (2018)

METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer
por: Chen, Xiaoxiang, et al.
Publicado: (2020)

METTL3-mediated N(6)-methyladenosine mRNA modification enhances long-term memory consolidation
por: Zhang, Zeyu, et al.
Publicado: (2018)

Roles of the m6A methyltransferases METTL3, METTL14, and WTAP in pulmonary tuberculosis
por: Zhang, Tian-Ping, et al.
Publicado: (2022)

β-Elemene Restrains PTEN mRNA Degradation to Restrain the Growth of Lung Cancer Cells via METTL3-Mediated N(6) Methyladenosine Modification
por: Feng, Yuxu, et al.
Publicado: (2022)

METTL14-mediated N(6)-methyladenosine modification of ITGB4 mRNA inhibits metastasis of clear cell renal cell carcinoma
por: Liu, Zhuonan, et al.
Publicado: (2022)

The N(6)-Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy
por: Dorn, Lisa E., et al.
Publicado: (2019)

METTL14 is a chromatin regulator independent of its RNA N(6)-methyladenosine methyltransferase activity
por: Dou, Xiaoyang, et al.
Publicado: (2023)

The METTL5-TRMT112 N(6)-methyladenosine methyltransferase complex regulates mRNA translation via 18S rRNA methylation
por: Sepich-Poore, Caraline, et al.
Publicado: (2022)

The Role of METTL3-Mediated N6-Methyladenosine (m6A) of JPH2 mRNA in Cyclophosphamide-Induced Cardiotoxicity
por: Zhu, Min, et al.
Publicado: (2021)

N(6)-methyladenosine (m(6)A) methyltransferase METTL3-mediated LINC00680 accelerates osteoarthritis through m(6)A/SIRT1 manner
por: Ren, Jiangdong, et al.
Publicado: (2022)

N6-Methyladenosine Methyltransferase METTL14-Mediated Autophagy in Malignant Development of Oral Squamous Cell Carcinoma
por: Wang, Fang, et al.
Publicado: (2021)

METTL3-mediated mRNA N(6)-methyladenosine is required for oocyte and follicle development in mice
por: Mu, Haiyuan, et al.
Publicado: (2021)

Alternative splicing of METTL3 explains apparently METTL3-independent m(6)A modifications in mRNA
por: Poh, Hui Xian, et al.
Publicado: (2022)

The m6A Methyltransferase METTL3 Is Functionally Implicated in DLBCL Development by Regulating m6A Modification in PEDF
por: Cheng, Yingying, et al.
Publicado: (2020)

Dynamic assembly of the mRNA m(6)A methyltransferase complex is regulated by METTL3 phase separation
por: Han, Dasol, et al.
Publicado: (2022)

DARS-AS1 recruits METTL3/METTL14 to bind and enhance DARS mRNA m(6)A modification and translation for cytoprotective autophagy in cervical cancer
por: Zhu, Miaohua, et al.
Publicado: (2022)

METTL3-mediated m(6)A mRNA modification of FBXW7 suppresses lung adenocarcinoma
por: Wu, Yingtong, et al.
Publicado: (2021)

The methyltransferase METTL3 promotes tumorigenesis via mediating HHLA2 mRNA m6A modification in human renal cell carcinoma
por: Zhu, Dawei, et al.
Publicado: (2022)

MiR-4729 regulates TIE1 mRNA m6A modification and angiogenesis in hemorrhoids by targeting METTL14
por: Liu, Te, et al.
Publicado: (2021)

METTL14 promotes migration and invasion of choroidal melanoma by targeting RUNX2 mRNA via m6A modification
por: Zhang, Xi, et al.
Publicado: (2022)

Levels and clinical significance of the m6A methyltransferase METTL14 in patients with coronary heart disease
por: Guo, Fengxia, et al.
Publicado: (2023)

METTL3-Mediated N6-Methyladenosine Modification of Trim59 mRNA Protects Against Sepsis-Induced Acute Respiratory Distress Syndrome
por: Chen, Yi, et al.
Publicado: (2022)

Crystal structure of human METTL6, the m(3)C methyltransferase
por: Chen, Ran, et al.
Publicado: (2021)

Multifaceted Roles of the N(6)-Methyladenosine RNA Methyltransferase METTL3 in Cancer and Immune Microenvironment
por: Hu, Chenxi, et al.
Publicado: (2022)

The N(6)-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity
por: Yoshinaga, Masanori, et al.
Publicado: (2022)

N(6)-Methyladenosine mRNA Modification: From Modification Site Selectivity to Neurological Functions
por: Zhang, Zeyu, et al.
Publicado: (2023)

Exploration of N6-Methyladenosine Profiles of mRNAs and the Function of METTL3 in Atherosclerosis
por: Zhou, Yaqing, et al.
Publicado: (2022)

N6-methyladenosine modification governs liver glycogenesis by stabilizing the glycogen synthase 2 mRNA
por: Zhang, Xiang, et al.
Publicado: (2022)

N (6)-methyladenosine modification and METTL3 modulate enterovirus 71 replication
por: Hao, Haojie, et al.
Publicado: (2019)

CSTF2 mediated mRNA N(6)-methyladenosine modification drives pancreatic ductal adenocarcinoma m(6)A subtypes
por: Zheng, Yanfen, et al.
Publicado: (2023)

N(6)-methyladenosine modification of ITGA6 mRNA promotes the development and progression of bladder cancer
por: Jin, Huan, et al.
Publicado: (2019)

Analysis of N6-Methyladenosine Methyltransferase Reveals METTL14 and ZC3H13 as Tumor Suppressor Genes in Breast Cancer
por: Gong, Peng-Ju, et al.
Publicado: (2020)

Conditional deficiency of m6A methyltransferase Mettl14 in substantia nigra alters dopaminergic neuron function
por: Teng, Yan, et al.
Publicado: (2021)

Kar4, the Yeast Homolog of METTL14, is Required for mRNA m(6)A Methylation and Meiosis
por: Park, Zachory M., et al.
Publicado: (2023)

Kar4, the yeast homolog of METTL14, is required for mRNA m(6)A methylation and meiosis
por: Park, Zachory M., et al.
Publicado: (2023)

METTL3 Is Involved in the Development of Graves’ Disease by Inducing SOCS mRNA m6A Modification
por: Song, Rong-hua, et al.
Publicado: (2021)

Methyltransferase-like 14 silencing relieves the development of atherosclerosis via m(6)A modification of p65 mRNA
por: Liu, Yingjie, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_l5igt8e3vtpc3gal8tneqv4319