Effects of Treatment of Coronavirus Disease 2019 With Convalescent Plasma in 25 B-Cell–Depleted Patients

Twenty-five B-cell–depleted patients (24 following anti-CD19/20 therapy) diagnosed with coronavirus disease 2019 had been symptomatic for a median of 26 days but remained antibody negative. All were treated with convalescent plasma with high neutralizing antibody titers. Twenty-one (84%) recovered,...

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Autores principales: Gharbharan, Arvind, GeurtsvanKessel, Corine H, Jordans, Carlijn C E, Blaauw, Marc, van der Klift, Marjolein, Hassing, Robert-Jan, Smits-Zwinkels, Marijn, Meertens, Maaike, van den Hout, Ella C, de Man, Anne Marie, Hageman, Ilse, Bogers, Susanne, van der Schoot, C Ellen, Swaneveld, Francis, Anas, Adam A, Rokx, Casper, Rijnders, Bart J A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406883/
https://www.ncbi.nlm.nih.gov/pubmed/34293119
http://dx.doi.org/10.1093/cid/ciab647
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author Gharbharan, Arvind
GeurtsvanKessel, Corine H
Jordans, Carlijn C E
Blaauw, Marc
van der Klift, Marjolein
Hassing, Robert-Jan
Smits-Zwinkels, Marijn
Meertens, Maaike
van den Hout, Ella C
de Man, Anne Marie
Hageman, Ilse
Bogers, Susanne
van der Schoot, C Ellen
Swaneveld, Francis
Anas, Adam A
Rokx, Casper
Rijnders, Bart J A
author_facet Gharbharan, Arvind
GeurtsvanKessel, Corine H
Jordans, Carlijn C E
Blaauw, Marc
van der Klift, Marjolein
Hassing, Robert-Jan
Smits-Zwinkels, Marijn
Meertens, Maaike
van den Hout, Ella C
de Man, Anne Marie
Hageman, Ilse
Bogers, Susanne
van der Schoot, C Ellen
Swaneveld, Francis
Anas, Adam A
Rokx, Casper
Rijnders, Bart J A
author_sort Gharbharan, Arvind
collection PubMed
description Twenty-five B-cell–depleted patients (24 following anti-CD19/20 therapy) diagnosed with coronavirus disease 2019 had been symptomatic for a median of 26 days but remained antibody negative. All were treated with convalescent plasma with high neutralizing antibody titers. Twenty-one (84%) recovered, indicating the potential therapeutic effects of this therapy in this particular population.
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spelling pubmed-84068832021-09-01 Effects of Treatment of Coronavirus Disease 2019 With Convalescent Plasma in 25 B-Cell–Depleted Patients Gharbharan, Arvind GeurtsvanKessel, Corine H Jordans, Carlijn C E Blaauw, Marc van der Klift, Marjolein Hassing, Robert-Jan Smits-Zwinkels, Marijn Meertens, Maaike van den Hout, Ella C de Man, Anne Marie Hageman, Ilse Bogers, Susanne van der Schoot, C Ellen Swaneveld, Francis Anas, Adam A Rokx, Casper Rijnders, Bart J A Clin Infect Dis Brief Reports Twenty-five B-cell–depleted patients (24 following anti-CD19/20 therapy) diagnosed with coronavirus disease 2019 had been symptomatic for a median of 26 days but remained antibody negative. All were treated with convalescent plasma with high neutralizing antibody titers. Twenty-one (84%) recovered, indicating the potential therapeutic effects of this therapy in this particular population. Oxford University Press 2021-07-22 /pmc/articles/PMC8406883/ /pubmed/34293119 http://dx.doi.org/10.1093/cid/ciab647 Text en © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Gharbharan, Arvind
GeurtsvanKessel, Corine H
Jordans, Carlijn C E
Blaauw, Marc
van der Klift, Marjolein
Hassing, Robert-Jan
Smits-Zwinkels, Marijn
Meertens, Maaike
van den Hout, Ella C
de Man, Anne Marie
Hageman, Ilse
Bogers, Susanne
van der Schoot, C Ellen
Swaneveld, Francis
Anas, Adam A
Rokx, Casper
Rijnders, Bart J A
Effects of Treatment of Coronavirus Disease 2019 With Convalescent Plasma in 25 B-Cell–Depleted Patients
title Effects of Treatment of Coronavirus Disease 2019 With Convalescent Plasma in 25 B-Cell–Depleted Patients
title_full Effects of Treatment of Coronavirus Disease 2019 With Convalescent Plasma in 25 B-Cell–Depleted Patients
title_fullStr Effects of Treatment of Coronavirus Disease 2019 With Convalescent Plasma in 25 B-Cell–Depleted Patients
title_full_unstemmed Effects of Treatment of Coronavirus Disease 2019 With Convalescent Plasma in 25 B-Cell–Depleted Patients
title_short Effects of Treatment of Coronavirus Disease 2019 With Convalescent Plasma in 25 B-Cell–Depleted Patients
title_sort effects of treatment of coronavirus disease 2019 with convalescent plasma in 25 b-cell–depleted patients
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406883/
https://www.ncbi.nlm.nih.gov/pubmed/34293119
http://dx.doi.org/10.1093/cid/ciab647
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