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Access to Procedural Memories After One Year: Evidence for Robust Memory Consolidation in Tourette Syndrome

Tourette syndrome is a childhood-onset neurodevelopmental disorder characterized by motor and vocal tics. On the neural level, tics are thought to be related to the disturbances of the cortico-basal ganglia-thalamo-cortical loops, which also play an important role in procedural learning. Several stu...

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Autores principales: Tóth-Fáber, Eszter, Tárnok, Zsanett, Takács, Ádám, Janacsek, Karolina, Németh, Dezső
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407083/
https://www.ncbi.nlm.nih.gov/pubmed/34475817
http://dx.doi.org/10.3389/fnhum.2021.715254
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author Tóth-Fáber, Eszter
Tárnok, Zsanett
Takács, Ádám
Janacsek, Karolina
Németh, Dezső
author_facet Tóth-Fáber, Eszter
Tárnok, Zsanett
Takács, Ádám
Janacsek, Karolina
Németh, Dezső
author_sort Tóth-Fáber, Eszter
collection PubMed
description Tourette syndrome is a childhood-onset neurodevelopmental disorder characterized by motor and vocal tics. On the neural level, tics are thought to be related to the disturbances of the cortico-basal ganglia-thalamo-cortical loops, which also play an important role in procedural learning. Several studies have investigated the acquisition of procedural information and the access to established procedural information in TS. Based on these, the notion of procedural hyperfunctioning, i.e., enhanced procedural learning, has been proposed. However, one neglected area is the retention of acquired procedural information, especially following a long-term offline period. Here, we investigated the 5-hour and 1-year consolidation of two aspects of procedural memory, namely serial-order and probability-based information. Nineteen children with TS between the ages of 10 and 15 as well as 19 typically developing gender- and age-matched controls were tested on a visuomotor four-choice reaction time task that enables the simultaneous assessment of the two aspects. They were retested on the same task 5 hours and 1 year later without any practice in the offline periods. Both groups successfully acquired and retained the probability-based information both when tested 5 hours and then 1 year later, with comparable performance between the TS and control groups. Children with TS did not acquire the serial-order information during the learning phase; hence, retention could not be reliably tested. Our study showed evidence for short-term and long-term retention of one aspect of procedural memory, namely probability-based information in TS, whereas learning of serial-order information might be impaired in this disorder.
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spelling pubmed-84070832021-09-01 Access to Procedural Memories After One Year: Evidence for Robust Memory Consolidation in Tourette Syndrome Tóth-Fáber, Eszter Tárnok, Zsanett Takács, Ádám Janacsek, Karolina Németh, Dezső Front Hum Neurosci Human Neuroscience Tourette syndrome is a childhood-onset neurodevelopmental disorder characterized by motor and vocal tics. On the neural level, tics are thought to be related to the disturbances of the cortico-basal ganglia-thalamo-cortical loops, which also play an important role in procedural learning. Several studies have investigated the acquisition of procedural information and the access to established procedural information in TS. Based on these, the notion of procedural hyperfunctioning, i.e., enhanced procedural learning, has been proposed. However, one neglected area is the retention of acquired procedural information, especially following a long-term offline period. Here, we investigated the 5-hour and 1-year consolidation of two aspects of procedural memory, namely serial-order and probability-based information. Nineteen children with TS between the ages of 10 and 15 as well as 19 typically developing gender- and age-matched controls were tested on a visuomotor four-choice reaction time task that enables the simultaneous assessment of the two aspects. They were retested on the same task 5 hours and 1 year later without any practice in the offline periods. Both groups successfully acquired and retained the probability-based information both when tested 5 hours and then 1 year later, with comparable performance between the TS and control groups. Children with TS did not acquire the serial-order information during the learning phase; hence, retention could not be reliably tested. Our study showed evidence for short-term and long-term retention of one aspect of procedural memory, namely probability-based information in TS, whereas learning of serial-order information might be impaired in this disorder. Frontiers Media S.A. 2021-08-12 /pmc/articles/PMC8407083/ /pubmed/34475817 http://dx.doi.org/10.3389/fnhum.2021.715254 Text en Copyright © 2021 Tóth-Fáber, Tárnok, Takács, Janacsek and Németh. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Human Neuroscience
Tóth-Fáber, Eszter
Tárnok, Zsanett
Takács, Ádám
Janacsek, Karolina
Németh, Dezső
Access to Procedural Memories After One Year: Evidence for Robust Memory Consolidation in Tourette Syndrome
title Access to Procedural Memories After One Year: Evidence for Robust Memory Consolidation in Tourette Syndrome
title_full Access to Procedural Memories After One Year: Evidence for Robust Memory Consolidation in Tourette Syndrome
title_fullStr Access to Procedural Memories After One Year: Evidence for Robust Memory Consolidation in Tourette Syndrome
title_full_unstemmed Access to Procedural Memories After One Year: Evidence for Robust Memory Consolidation in Tourette Syndrome
title_short Access to Procedural Memories After One Year: Evidence for Robust Memory Consolidation in Tourette Syndrome
title_sort access to procedural memories after one year: evidence for robust memory consolidation in tourette syndrome
topic Human Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407083/
https://www.ncbi.nlm.nih.gov/pubmed/34475817
http://dx.doi.org/10.3389/fnhum.2021.715254
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