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Selecting software pipelines for change in flortaucipir SUVR: Balancing repeatability and group separation

Since tau PET tracers were introduced, investigators have quantified them using a wide variety of automated methods. As longitudinal cohort studies acquire second and third time points of serial within-person tau PET data, determining the best pipeline to measure change has become crucial. We compar...

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Autores principales: Schwarz, Christopher G., Therneau, Terry M., Weigand, Stephen D., Gunter, Jeffrey L., Lowe, Val J., Przybelski, Scott A., Senjem, Matthew L., Botha, Hugo, Vemuri, Prashanthi, Kantarci, Kejal, Boeve, Bradley F., Whitwell, Jennifer L., Josephs, Keith A., Petersen, Ronald C., Knopman, David S., Jack, Clifford R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407434/
https://www.ncbi.nlm.nih.gov/pubmed/34118395
http://dx.doi.org/10.1016/j.neuroimage.2021.118259
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author Schwarz, Christopher G.
Therneau, Terry M.
Weigand, Stephen D.
Gunter, Jeffrey L.
Lowe, Val J.
Przybelski, Scott A.
Senjem, Matthew L.
Botha, Hugo
Vemuri, Prashanthi
Kantarci, Kejal
Boeve, Bradley F.
Whitwell, Jennifer L.
Josephs, Keith A.
Petersen, Ronald C.
Knopman, David S.
Jack, Clifford R.
author_facet Schwarz, Christopher G.
Therneau, Terry M.
Weigand, Stephen D.
Gunter, Jeffrey L.
Lowe, Val J.
Przybelski, Scott A.
Senjem, Matthew L.
Botha, Hugo
Vemuri, Prashanthi
Kantarci, Kejal
Boeve, Bradley F.
Whitwell, Jennifer L.
Josephs, Keith A.
Petersen, Ronald C.
Knopman, David S.
Jack, Clifford R.
author_sort Schwarz, Christopher G.
collection PubMed
description Since tau PET tracers were introduced, investigators have quantified them using a wide variety of automated methods. As longitudinal cohort studies acquire second and third time points of serial within-person tau PET data, determining the best pipeline to measure change has become crucial. We compared a total of 415 different quantification methods (each a combination of multiple options) according to their effects on a) differences in annual SUVR change between clinical groups, and b) longitudinal measurement repeatability as measured by the error term from a linear mixed-effects model. Our comparisons used MRI and Flortaucipir scans of 97 Mayo Clinic study participants who clinically either: a) were cognitively unimpaired, or b) had cognitive impairments that were consistent with Alzheimer’s disease pathology. Tested methods included cross-sectional and longitudinal variants of two overarching pipelines (FreeSurfer 6.0, and an in-house pipeline based on SPM12), three choices of target region (entorhinal, inferior temporal, and a temporal lobe meta-ROI), five types of partial volume correction (PVC) (none, two-compartment, three-compartment, geometric transfer matrix (GTM), and a tau-specific GTM variant), seven choices of reference region (cerebellar crus, cerebellar gray matter, whole cerebellum, pons, supratentorial white matter, eroded supratentorial WM, and a composite of eroded supratentorial WM, pons, and whole cerebellum), two choices of region masking (GM or GM and WM), and two choices of statistic (voxel-wise mean vs. median). Our strongest findings were: 1) larger temporal-lobe target regions greatly outperformed entorhinal cortex (median sample size estimates based on a hypothetical clinical trial were 520–526 vs. 1740); 2) longitudinal processing pipelines outperformed cross-sectional pipelines (median sample size estimates were 483 vs. 572); and 3) reference regions including supratentorial WM outperformed traditional cerebellar and pontine options (median sample size estimates were 370 vs. 559). Altogether, our results favored longitudinally SUVR methods and a temporal-lobe meta-ROI that includes adjacent (juxtacortical) WM, a composite reference region (eroded supratentorial WM + pons + whole cerebellum), 2-class voxel-based PVC, and median statistics.
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spelling pubmed-84074342021-09-01 Selecting software pipelines for change in flortaucipir SUVR: Balancing repeatability and group separation Schwarz, Christopher G. Therneau, Terry M. Weigand, Stephen D. Gunter, Jeffrey L. Lowe, Val J. Przybelski, Scott A. Senjem, Matthew L. Botha, Hugo Vemuri, Prashanthi Kantarci, Kejal Boeve, Bradley F. Whitwell, Jennifer L. Josephs, Keith A. Petersen, Ronald C. Knopman, David S. Jack, Clifford R. Neuroimage Article Since tau PET tracers were introduced, investigators have quantified them using a wide variety of automated methods. As longitudinal cohort studies acquire second and third time points of serial within-person tau PET data, determining the best pipeline to measure change has become crucial. We compared a total of 415 different quantification methods (each a combination of multiple options) according to their effects on a) differences in annual SUVR change between clinical groups, and b) longitudinal measurement repeatability as measured by the error term from a linear mixed-effects model. Our comparisons used MRI and Flortaucipir scans of 97 Mayo Clinic study participants who clinically either: a) were cognitively unimpaired, or b) had cognitive impairments that were consistent with Alzheimer’s disease pathology. Tested methods included cross-sectional and longitudinal variants of two overarching pipelines (FreeSurfer 6.0, and an in-house pipeline based on SPM12), three choices of target region (entorhinal, inferior temporal, and a temporal lobe meta-ROI), five types of partial volume correction (PVC) (none, two-compartment, three-compartment, geometric transfer matrix (GTM), and a tau-specific GTM variant), seven choices of reference region (cerebellar crus, cerebellar gray matter, whole cerebellum, pons, supratentorial white matter, eroded supratentorial WM, and a composite of eroded supratentorial WM, pons, and whole cerebellum), two choices of region masking (GM or GM and WM), and two choices of statistic (voxel-wise mean vs. median). Our strongest findings were: 1) larger temporal-lobe target regions greatly outperformed entorhinal cortex (median sample size estimates based on a hypothetical clinical trial were 520–526 vs. 1740); 2) longitudinal processing pipelines outperformed cross-sectional pipelines (median sample size estimates were 483 vs. 572); and 3) reference regions including supratentorial WM outperformed traditional cerebellar and pontine options (median sample size estimates were 370 vs. 559). Altogether, our results favored longitudinally SUVR methods and a temporal-lobe meta-ROI that includes adjacent (juxtacortical) WM, a composite reference region (eroded supratentorial WM + pons + whole cerebellum), 2-class voxel-based PVC, and median statistics. 2021-06-09 2021-09 /pmc/articles/PMC8407434/ /pubmed/34118395 http://dx.doi.org/10.1016/j.neuroimage.2021.118259 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Article
Schwarz, Christopher G.
Therneau, Terry M.
Weigand, Stephen D.
Gunter, Jeffrey L.
Lowe, Val J.
Przybelski, Scott A.
Senjem, Matthew L.
Botha, Hugo
Vemuri, Prashanthi
Kantarci, Kejal
Boeve, Bradley F.
Whitwell, Jennifer L.
Josephs, Keith A.
Petersen, Ronald C.
Knopman, David S.
Jack, Clifford R.
Selecting software pipelines for change in flortaucipir SUVR: Balancing repeatability and group separation
title Selecting software pipelines for change in flortaucipir SUVR: Balancing repeatability and group separation
title_full Selecting software pipelines for change in flortaucipir SUVR: Balancing repeatability and group separation
title_fullStr Selecting software pipelines for change in flortaucipir SUVR: Balancing repeatability and group separation
title_full_unstemmed Selecting software pipelines for change in flortaucipir SUVR: Balancing repeatability and group separation
title_short Selecting software pipelines for change in flortaucipir SUVR: Balancing repeatability and group separation
title_sort selecting software pipelines for change in flortaucipir suvr: balancing repeatability and group separation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407434/
https://www.ncbi.nlm.nih.gov/pubmed/34118395
http://dx.doi.org/10.1016/j.neuroimage.2021.118259
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