Cargando…

Impact of the dog population and household environment for the maintenance of natural foci of Leishmania infantum transmission to human and animal hosts in endemic areas for visceral leishmaniasis in Sao Paulo state, Brazil

When it comes to visceral leishmaniasis (VL) in Brazil, one of the main targets of public health policies of surveillance is the control of domestic canine reservoirs of Leishmania infantum. This paper aims to evaluate the effect of the dog population and household environment for the maintenance of...

Descripción completa

Detalles Bibliográficos
Autores principales: Matsumoto, Patricia Sayuri Silvestre, Hiramoto, Roberto Mitsuyoshi, Pereira, Virgínia Bodelão Richini, Camprigher, Valéria Medina, Taniguchi, Helena Hilomi, de Raeffray Barbosa, José Eduardo, Cortez, Luiz Ricardo Paes de Barros, Fonseca, Elivelton da Silva, Guimarães, Raul Borges, Tolezano, José Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407543/
https://www.ncbi.nlm.nih.gov/pubmed/34464421
http://dx.doi.org/10.1371/journal.pone.0256534
_version_ 1783746641887494144
author Matsumoto, Patricia Sayuri Silvestre
Hiramoto, Roberto Mitsuyoshi
Pereira, Virgínia Bodelão Richini
Camprigher, Valéria Medina
Taniguchi, Helena Hilomi
de Raeffray Barbosa, José Eduardo
Cortez, Luiz Ricardo Paes de Barros
Fonseca, Elivelton da Silva
Guimarães, Raul Borges
Tolezano, José Eduardo
author_facet Matsumoto, Patricia Sayuri Silvestre
Hiramoto, Roberto Mitsuyoshi
Pereira, Virgínia Bodelão Richini
Camprigher, Valéria Medina
Taniguchi, Helena Hilomi
de Raeffray Barbosa, José Eduardo
Cortez, Luiz Ricardo Paes de Barros
Fonseca, Elivelton da Silva
Guimarães, Raul Borges
Tolezano, José Eduardo
author_sort Matsumoto, Patricia Sayuri Silvestre
collection PubMed
description When it comes to visceral leishmaniasis (VL) in Brazil, one of the main targets of public health policies of surveillance is the control of domestic canine reservoirs of Leishmania infantum. This paper aims to evaluate the effect of the dog population and household environment for the maintenance of natural foci in the transmission to human and animal hosts in an endemic city for VL, Bauru, in Brazil. We collected 6,578 blood samples of dogs living in 3,916 households from Nov.2019 to Mar.2020 and applied geospatial models to predict the disease risk based on the canine population. We used Kernel density estimation, cluster analysis, geostatistics, and Generalized Additive Models (GAM). To validate our models, we used cross-validation and created a receiver operating characteristic (ROC) curve. We found an overall canine VL (CVL) seroprevalence of 5.6% for the sampled dogs, while for the households, the positivity rate was 8.7%. Odds ratios (OR) for CVL increased progressively according to the number of canines for >2 dogs (OR 2.70); households that already had CVL in the past increased the chances for CVL currently (OR 2.73); and the cases of CVL increase the chances for human VL cases (OR 1.16). Our models were statistically significant and demonstrated a spatial association between canine and human disease cases, mainly in VL foci that remain endemic. Although the Kernel density ratio map had the best performance (AUC = 82), all the models showed high risk in the city’s northwest area. Canine population dynamics must be considered in public policies, and geospatial methods may help target priority areas and planning VL surveillance in low and middle-income countries.
format Online
Article
Text
id pubmed-8407543
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-84075432021-09-01 Impact of the dog population and household environment for the maintenance of natural foci of Leishmania infantum transmission to human and animal hosts in endemic areas for visceral leishmaniasis in Sao Paulo state, Brazil Matsumoto, Patricia Sayuri Silvestre Hiramoto, Roberto Mitsuyoshi Pereira, Virgínia Bodelão Richini Camprigher, Valéria Medina Taniguchi, Helena Hilomi de Raeffray Barbosa, José Eduardo Cortez, Luiz Ricardo Paes de Barros Fonseca, Elivelton da Silva Guimarães, Raul Borges Tolezano, José Eduardo PLoS One Research Article When it comes to visceral leishmaniasis (VL) in Brazil, one of the main targets of public health policies of surveillance is the control of domestic canine reservoirs of Leishmania infantum. This paper aims to evaluate the effect of the dog population and household environment for the maintenance of natural foci in the transmission to human and animal hosts in an endemic city for VL, Bauru, in Brazil. We collected 6,578 blood samples of dogs living in 3,916 households from Nov.2019 to Mar.2020 and applied geospatial models to predict the disease risk based on the canine population. We used Kernel density estimation, cluster analysis, geostatistics, and Generalized Additive Models (GAM). To validate our models, we used cross-validation and created a receiver operating characteristic (ROC) curve. We found an overall canine VL (CVL) seroprevalence of 5.6% for the sampled dogs, while for the households, the positivity rate was 8.7%. Odds ratios (OR) for CVL increased progressively according to the number of canines for >2 dogs (OR 2.70); households that already had CVL in the past increased the chances for CVL currently (OR 2.73); and the cases of CVL increase the chances for human VL cases (OR 1.16). Our models were statistically significant and demonstrated a spatial association between canine and human disease cases, mainly in VL foci that remain endemic. Although the Kernel density ratio map had the best performance (AUC = 82), all the models showed high risk in the city’s northwest area. Canine population dynamics must be considered in public policies, and geospatial methods may help target priority areas and planning VL surveillance in low and middle-income countries. Public Library of Science 2021-08-31 /pmc/articles/PMC8407543/ /pubmed/34464421 http://dx.doi.org/10.1371/journal.pone.0256534 Text en © 2021 Matsumoto et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Matsumoto, Patricia Sayuri Silvestre
Hiramoto, Roberto Mitsuyoshi
Pereira, Virgínia Bodelão Richini
Camprigher, Valéria Medina
Taniguchi, Helena Hilomi
de Raeffray Barbosa, José Eduardo
Cortez, Luiz Ricardo Paes de Barros
Fonseca, Elivelton da Silva
Guimarães, Raul Borges
Tolezano, José Eduardo
Impact of the dog population and household environment for the maintenance of natural foci of Leishmania infantum transmission to human and animal hosts in endemic areas for visceral leishmaniasis in Sao Paulo state, Brazil
title Impact of the dog population and household environment for the maintenance of natural foci of Leishmania infantum transmission to human and animal hosts in endemic areas for visceral leishmaniasis in Sao Paulo state, Brazil
title_full Impact of the dog population and household environment for the maintenance of natural foci of Leishmania infantum transmission to human and animal hosts in endemic areas for visceral leishmaniasis in Sao Paulo state, Brazil
title_fullStr Impact of the dog population and household environment for the maintenance of natural foci of Leishmania infantum transmission to human and animal hosts in endemic areas for visceral leishmaniasis in Sao Paulo state, Brazil
title_full_unstemmed Impact of the dog population and household environment for the maintenance of natural foci of Leishmania infantum transmission to human and animal hosts in endemic areas for visceral leishmaniasis in Sao Paulo state, Brazil
title_short Impact of the dog population and household environment for the maintenance of natural foci of Leishmania infantum transmission to human and animal hosts in endemic areas for visceral leishmaniasis in Sao Paulo state, Brazil
title_sort impact of the dog population and household environment for the maintenance of natural foci of leishmania infantum transmission to human and animal hosts in endemic areas for visceral leishmaniasis in sao paulo state, brazil
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407543/
https://www.ncbi.nlm.nih.gov/pubmed/34464421
http://dx.doi.org/10.1371/journal.pone.0256534
work_keys_str_mv AT matsumotopatriciasayurisilvestre impactofthedogpopulationandhouseholdenvironmentforthemaintenanceofnaturalfociofleishmaniainfantumtransmissiontohumanandanimalhostsinendemicareasforvisceralleishmaniasisinsaopaulostatebrazil
AT hiramotorobertomitsuyoshi impactofthedogpopulationandhouseholdenvironmentforthemaintenanceofnaturalfociofleishmaniainfantumtransmissiontohumanandanimalhostsinendemicareasforvisceralleishmaniasisinsaopaulostatebrazil
AT pereiravirginiabodelaorichini impactofthedogpopulationandhouseholdenvironmentforthemaintenanceofnaturalfociofleishmaniainfantumtransmissiontohumanandanimalhostsinendemicareasforvisceralleishmaniasisinsaopaulostatebrazil
AT camprighervaleriamedina impactofthedogpopulationandhouseholdenvironmentforthemaintenanceofnaturalfociofleishmaniainfantumtransmissiontohumanandanimalhostsinendemicareasforvisceralleishmaniasisinsaopaulostatebrazil
AT taniguchihelenahilomi impactofthedogpopulationandhouseholdenvironmentforthemaintenanceofnaturalfociofleishmaniainfantumtransmissiontohumanandanimalhostsinendemicareasforvisceralleishmaniasisinsaopaulostatebrazil
AT deraeffraybarbosajoseeduardo impactofthedogpopulationandhouseholdenvironmentforthemaintenanceofnaturalfociofleishmaniainfantumtransmissiontohumanandanimalhostsinendemicareasforvisceralleishmaniasisinsaopaulostatebrazil
AT cortezluizricardopaesdebarros impactofthedogpopulationandhouseholdenvironmentforthemaintenanceofnaturalfociofleishmaniainfantumtransmissiontohumanandanimalhostsinendemicareasforvisceralleishmaniasisinsaopaulostatebrazil
AT fonsecaeliveltondasilva impactofthedogpopulationandhouseholdenvironmentforthemaintenanceofnaturalfociofleishmaniainfantumtransmissiontohumanandanimalhostsinendemicareasforvisceralleishmaniasisinsaopaulostatebrazil
AT guimaraesraulborges impactofthedogpopulationandhouseholdenvironmentforthemaintenanceofnaturalfociofleishmaniainfantumtransmissiontohumanandanimalhostsinendemicareasforvisceralleishmaniasisinsaopaulostatebrazil
AT tolezanojoseeduardo impactofthedogpopulationandhouseholdenvironmentforthemaintenanceofnaturalfociofleishmaniainfantumtransmissiontohumanandanimalhostsinendemicareasforvisceralleishmaniasisinsaopaulostatebrazil