TNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation

In this issue of PLOS Biology, Zhang and colleagues unveil a complex midgestational death during embryogenesis of mice harboring caspase-8 cleavage-resistant receptor-interacting protein (RIP) kinase (RIPK)1. Tumor necrosis factor (TNF) receptor (TNFR)1-dependent signaling drives cell death through...

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Detalles Bibliográficos
Autores principales: Mocarski, Edward S., Mandal, Pratyusha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Primer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407551/
https://www.ncbi.nlm.nih.gov/pubmed/34464377
http://dx.doi.org/10.1371/journal.pbio.3001371
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author Mocarski, Edward S.
Mandal, Pratyusha
author_facet Mocarski, Edward S.
Mandal, Pratyusha
author_sort Mocarski, Edward S.
collection PubMed
description In this issue of PLOS Biology, Zhang and colleagues unveil a complex midgestational death during embryogenesis of mice harboring caspase-8 cleavage-resistant receptor-interacting protein (RIP) kinase (RIPK)1. Tumor necrosis factor (TNF) receptor (TNFR)1-dependent signaling drives cell death through a novel pathway requiring synergism between apoptotic and pyroptotic caspases.
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spelling pubmed-84075512021-09-01 TNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation Mocarski, Edward S. Mandal, Pratyusha PLoS Biol Primer In this issue of PLOS Biology, Zhang and colleagues unveil a complex midgestational death during embryogenesis of mice harboring caspase-8 cleavage-resistant receptor-interacting protein (RIP) kinase (RIPK)1. Tumor necrosis factor (TNF) receptor (TNFR)1-dependent signaling drives cell death through a novel pathway requiring synergism between apoptotic and pyroptotic caspases. Public Library of Science 2021-08-31 /pmc/articles/PMC8407551/ /pubmed/34464377 http://dx.doi.org/10.1371/journal.pbio.3001371 Text en © 2021 Mocarski, Mandal https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Primer
Mocarski, Edward S.
Mandal, Pratyusha
TNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation
title TNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation
title_full TNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation
title_fullStr TNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation
title_full_unstemmed TNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation
title_short TNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation
title_sort tnf-dependent hyperactivation of ripk1-dependent cytotoxic signaling during embryogenesis and inflammation
topic Primer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407551/
https://www.ncbi.nlm.nih.gov/pubmed/34464377
http://dx.doi.org/10.1371/journal.pbio.3001371
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AT mandalpratyusha tnfdependenthyperactivationofripk1dependentcytotoxicsignalingduringembryogenesisandinflammation

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