EGFRAP encodes a new negative regulator of the EGFR acting in both normal and oncogenic EGFR/Ras-driven tissue morphogenesis

Activation of Ras signaling occurs in ~30% of human cancers. However, activated Ras alone is insufficient to produce malignancy. Thus, it is imperative to identify those genes cooperating with activated Ras in driving tumoral growth. In this work, we have identified a novel EGFR inhibitor, which we...

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Detalles Bibliográficos
Autores principales: Soler Beatty, Jennifer, Molnar, Cristina, Luque, Carlos M., de Celis, Jose F., Martín-Bermudo, María D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407591/
https://www.ncbi.nlm.nih.gov/pubmed/34411095
http://dx.doi.org/10.1371/journal.pgen.1009738

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407591/
https://www.ncbi.nlm.nih.gov/pubmed/34411095
http://dx.doi.org/10.1371/journal.pgen.1009738

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