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Hybrid reflection retrieval method for terahertz dielectric imaging of human bone
Terahertz imaging is becoming a biological imaging modality in its own right, alongside the more mature infrared and X-ray techniques. Nevertheless, extraction of hyperspectral, biometric information of samples is limited by experimental challenges. Terahertz time domain spectroscopy reflection meas...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Optical Society of America
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407848/ https://www.ncbi.nlm.nih.gov/pubmed/34513226 http://dx.doi.org/10.1364/BOE.427648 |
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author | Freer, Suzanna Sui, Cong Hanham, Stephen M. Grover, Liam M. Navarro-Cía, Miguel |
author_facet | Freer, Suzanna Sui, Cong Hanham, Stephen M. Grover, Liam M. Navarro-Cía, Miguel |
author_sort | Freer, Suzanna |
collection | PubMed |
description | Terahertz imaging is becoming a biological imaging modality in its own right, alongside the more mature infrared and X-ray techniques. Nevertheless, extraction of hyperspectral, biometric information of samples is limited by experimental challenges. Terahertz time domain spectroscopy reflection measurements demand highly precise alignment and suffer from limitations of the sample thickness. In this work, a novel hybrid Kramers-Kronig and Fabry-Pérot based algorithm has been developed to overcome these challenges. While its application is demonstrated through dielectric retrieval of glass-backed human bone slices for prospective characterisation of metastatic defects or osteoporosis, the generality of the algorithm offers itself to wider application towards biological materials. |
format | Online Article Text |
id | pubmed-8407848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Optical Society of America |
record_format | MEDLINE/PubMed |
spelling | pubmed-84078482021-09-10 Hybrid reflection retrieval method for terahertz dielectric imaging of human bone Freer, Suzanna Sui, Cong Hanham, Stephen M. Grover, Liam M. Navarro-Cía, Miguel Biomed Opt Express Article Terahertz imaging is becoming a biological imaging modality in its own right, alongside the more mature infrared and X-ray techniques. Nevertheless, extraction of hyperspectral, biometric information of samples is limited by experimental challenges. Terahertz time domain spectroscopy reflection measurements demand highly precise alignment and suffer from limitations of the sample thickness. In this work, a novel hybrid Kramers-Kronig and Fabry-Pérot based algorithm has been developed to overcome these challenges. While its application is demonstrated through dielectric retrieval of glass-backed human bone slices for prospective characterisation of metastatic defects or osteoporosis, the generality of the algorithm offers itself to wider application towards biological materials. Optical Society of America 2021-07-12 /pmc/articles/PMC8407848/ /pubmed/34513226 http://dx.doi.org/10.1364/BOE.427648 Text en Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI. https://creativecommons.org/licenses/by/4.0/https://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Freer, Suzanna Sui, Cong Hanham, Stephen M. Grover, Liam M. Navarro-Cía, Miguel Hybrid reflection retrieval method for terahertz dielectric imaging of human bone |
title | Hybrid reflection retrieval method for terahertz dielectric imaging of human bone |
title_full | Hybrid reflection retrieval method for terahertz dielectric imaging of human bone |
title_fullStr | Hybrid reflection retrieval method for terahertz dielectric imaging of human bone |
title_full_unstemmed | Hybrid reflection retrieval method for terahertz dielectric imaging of human bone |
title_short | Hybrid reflection retrieval method for terahertz dielectric imaging of human bone |
title_sort | hybrid reflection retrieval method for terahertz dielectric imaging of human bone |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407848/ https://www.ncbi.nlm.nih.gov/pubmed/34513226 http://dx.doi.org/10.1364/BOE.427648 |
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