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Extracellular Vesicles in Premature Aging and Diseases in Adulthood Due to Developmental Exposures
The developmental origins of health and disease (DOHaD) is a paradigm that links prenatal and early life exposures that occur during crucial periods of development to health outcome and risk of disease later in life. Maternal exposures to stress, some psychoactive drugs and alcohol, and environmenta...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
JKL International LLC
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407878/ https://www.ncbi.nlm.nih.gov/pubmed/34527425 http://dx.doi.org/10.14336/AD.2021.0322 |
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author | Pinson, Marisa R Chung, Dae D Adams, Amy M Scopice, Chiara Payne, Elizabeth A Sivakumar, Monisha Miranda, Rajesh C |
author_facet | Pinson, Marisa R Chung, Dae D Adams, Amy M Scopice, Chiara Payne, Elizabeth A Sivakumar, Monisha Miranda, Rajesh C |
author_sort | Pinson, Marisa R |
collection | PubMed |
description | The developmental origins of health and disease (DOHaD) is a paradigm that links prenatal and early life exposures that occur during crucial periods of development to health outcome and risk of disease later in life. Maternal exposures to stress, some psychoactive drugs and alcohol, and environmental chemicals, among others, may result in functional changes in developing fetal tissues, creating a predisposition for disease in the individual as they age. Extracellular vesicles (EVs) may be mediators of both the immediate effects of exposure during development and early childhood as well as the long-term consequences of exposure that lead to increased risk and disease severity later in life. Given the prevalence of diseases with developmental origins, such as cardiovascular disease, neurodegenerative disorders, osteoporosis, metabolic dysfunction, and cancer, it is important to identify persistent mediators of disease risk. In this review, we take this approach, viewing diseases typically associated with aging in light of early life exposures and discuss the potential role of EVs as mediators of lasting consequences. |
format | Online Article Text |
id | pubmed-8407878 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | JKL International LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-84078782021-09-14 Extracellular Vesicles in Premature Aging and Diseases in Adulthood Due to Developmental Exposures Pinson, Marisa R Chung, Dae D Adams, Amy M Scopice, Chiara Payne, Elizabeth A Sivakumar, Monisha Miranda, Rajesh C Aging Dis Review The developmental origins of health and disease (DOHaD) is a paradigm that links prenatal and early life exposures that occur during crucial periods of development to health outcome and risk of disease later in life. Maternal exposures to stress, some psychoactive drugs and alcohol, and environmental chemicals, among others, may result in functional changes in developing fetal tissues, creating a predisposition for disease in the individual as they age. Extracellular vesicles (EVs) may be mediators of both the immediate effects of exposure during development and early childhood as well as the long-term consequences of exposure that lead to increased risk and disease severity later in life. Given the prevalence of diseases with developmental origins, such as cardiovascular disease, neurodegenerative disorders, osteoporosis, metabolic dysfunction, and cancer, it is important to identify persistent mediators of disease risk. In this review, we take this approach, viewing diseases typically associated with aging in light of early life exposures and discuss the potential role of EVs as mediators of lasting consequences. JKL International LLC 2021-09-01 /pmc/articles/PMC8407878/ /pubmed/34527425 http://dx.doi.org/10.14336/AD.2021.0322 Text en Copyright: © 2021 Pinson et al. https://creativecommons.org/licenses/by/2.0/this is an open access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Review Pinson, Marisa R Chung, Dae D Adams, Amy M Scopice, Chiara Payne, Elizabeth A Sivakumar, Monisha Miranda, Rajesh C Extracellular Vesicles in Premature Aging and Diseases in Adulthood Due to Developmental Exposures |
title | Extracellular Vesicles in Premature Aging and Diseases in Adulthood Due to Developmental Exposures |
title_full | Extracellular Vesicles in Premature Aging and Diseases in Adulthood Due to Developmental Exposures |
title_fullStr | Extracellular Vesicles in Premature Aging and Diseases in Adulthood Due to Developmental Exposures |
title_full_unstemmed | Extracellular Vesicles in Premature Aging and Diseases in Adulthood Due to Developmental Exposures |
title_short | Extracellular Vesicles in Premature Aging and Diseases in Adulthood Due to Developmental Exposures |
title_sort | extracellular vesicles in premature aging and diseases in adulthood due to developmental exposures |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407878/ https://www.ncbi.nlm.nih.gov/pubmed/34527425 http://dx.doi.org/10.14336/AD.2021.0322 |
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