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Thiol level and total oxidant/antioxidant status in patients with COVID-19 infection
BACKGROUND: Accumulating evidence suggests that oxidative stress is closely related to the pathogenesis and severity of COVID-19 infection. Here, we attempted to compare thiol, total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) levels between COVID-19 patien...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407933/ https://www.ncbi.nlm.nih.gov/pubmed/34467472 http://dx.doi.org/10.1007/s11845-021-02743-8 |
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author | Çakırca, Gökhan Damar Çakırca, Tuba Üstünel, Murat Torun, Ayşe Koyuncu, İsmail |
author_facet | Çakırca, Gökhan Damar Çakırca, Tuba Üstünel, Murat Torun, Ayşe Koyuncu, İsmail |
author_sort | Çakırca, Gökhan |
collection | PubMed |
description | BACKGROUND: Accumulating evidence suggests that oxidative stress is closely related to the pathogenesis and severity of COVID-19 infection. Here, we attempted to compare thiol, total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) levels between COVID-19 patients who need and do not need intensive care unit (ICU) support, and determine whether these markers could be used as predictors of ICU admission. METHODS: We recruited 86 patients with COVID-19 infection and classified them into two groups according to the level of care: ICU group (n = 40) and non-ICU group (n = 46). Thiol, TAS, TOS, and OSI levels were determined and compared between the two groups. RESULTS: The levels of thiol and TAS in serum were markedly lower in ICU patients than in the non-ICU patients. On the contrary, TOS and OSI levels were markedly higher. Inflammatory markers, including white blood cell, neutrophil, C-reactive protein, procalcitonin, and ferritin, were negatively correlated with the thiol and TAS, and positively correlated with the TOS and OSI. We determined that areas under the ROC curve for thiol, TAS, TOS, and OSI were 0.799, 0.778, 0.713, and 0.780, respectively. CONCLUSIONS: Our results revealed that the increase in oxidative stress and decrease in antioxidant levels in COVID-19-infected patients were associated with worsening of disease. Thiol, TAS, TOS, and OSI parameters can be used to distinguish between ICU patients and those who do not, among which thiol was the best predictor of ICU requirement. |
format | Online Article Text |
id | pubmed-8407933 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-84079332021-09-01 Thiol level and total oxidant/antioxidant status in patients with COVID-19 infection Çakırca, Gökhan Damar Çakırca, Tuba Üstünel, Murat Torun, Ayşe Koyuncu, İsmail Ir J Med Sci Original Article BACKGROUND: Accumulating evidence suggests that oxidative stress is closely related to the pathogenesis and severity of COVID-19 infection. Here, we attempted to compare thiol, total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) levels between COVID-19 patients who need and do not need intensive care unit (ICU) support, and determine whether these markers could be used as predictors of ICU admission. METHODS: We recruited 86 patients with COVID-19 infection and classified them into two groups according to the level of care: ICU group (n = 40) and non-ICU group (n = 46). Thiol, TAS, TOS, and OSI levels were determined and compared between the two groups. RESULTS: The levels of thiol and TAS in serum were markedly lower in ICU patients than in the non-ICU patients. On the contrary, TOS and OSI levels were markedly higher. Inflammatory markers, including white blood cell, neutrophil, C-reactive protein, procalcitonin, and ferritin, were negatively correlated with the thiol and TAS, and positively correlated with the TOS and OSI. We determined that areas under the ROC curve for thiol, TAS, TOS, and OSI were 0.799, 0.778, 0.713, and 0.780, respectively. CONCLUSIONS: Our results revealed that the increase in oxidative stress and decrease in antioxidant levels in COVID-19-infected patients were associated with worsening of disease. Thiol, TAS, TOS, and OSI parameters can be used to distinguish between ICU patients and those who do not, among which thiol was the best predictor of ICU requirement. Springer International Publishing 2021-09-01 2022 /pmc/articles/PMC8407933/ /pubmed/34467472 http://dx.doi.org/10.1007/s11845-021-02743-8 Text en © Royal Academy of Medicine in Ireland 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Original Article Çakırca, Gökhan Damar Çakırca, Tuba Üstünel, Murat Torun, Ayşe Koyuncu, İsmail Thiol level and total oxidant/antioxidant status in patients with COVID-19 infection |
title | Thiol level and total oxidant/antioxidant status in patients with COVID-19 infection |
title_full | Thiol level and total oxidant/antioxidant status in patients with COVID-19 infection |
title_fullStr | Thiol level and total oxidant/antioxidant status in patients with COVID-19 infection |
title_full_unstemmed | Thiol level and total oxidant/antioxidant status in patients with COVID-19 infection |
title_short | Thiol level and total oxidant/antioxidant status in patients with COVID-19 infection |
title_sort | thiol level and total oxidant/antioxidant status in patients with covid-19 infection |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407933/ https://www.ncbi.nlm.nih.gov/pubmed/34467472 http://dx.doi.org/10.1007/s11845-021-02743-8 |
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