D614G mutation eventuates in all VOI and VOC in SARS-CoV-2: Is it part of the positive selection pioneered by Darwin?

Recently, several emerging variants of SARS-CoV-2 have originated from the Wuhan strain and spread throughout the globe within one and a half years. One mutation, D614G, is very prominent in all VOI and VOC in SARS-CoV-2. This mutation might help to increase the viral fitness in all emerging variant...

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Autores principales: Chakraborty, Chiranjib, Saha, Abinit, Sharma, Ashish Ranjan, Bhattacharya, Manojit, Lee, Sang-Soo, Agoramoorthy, Govindasamy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408019/
https://www.ncbi.nlm.nih.gov/pubmed/34484868
http://dx.doi.org/10.1016/j.omtn.2021.07.011
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author Chakraborty, Chiranjib
Saha, Abinit
Sharma, Ashish Ranjan
Bhattacharya, Manojit
Lee, Sang-Soo
Agoramoorthy, Govindasamy
author_facet Chakraborty, Chiranjib
Saha, Abinit
Sharma, Ashish Ranjan
Bhattacharya, Manojit
Lee, Sang-Soo
Agoramoorthy, Govindasamy
author_sort Chakraborty, Chiranjib
collection PubMed
description Recently, several emerging variants of SARS-CoV-2 have originated from the Wuhan strain and spread throughout the globe within one and a half years. One mutation, D614G, is very prominent in all VOI and VOC in SARS-CoV-2. This mutation might help to increase the viral fitness in all emerging variants where the mutation is present. With the help of this mutation (D614G), the SARS-CoV-2 variants have gained viral fitness to enhance viral replication and increase transmission. This paper attempts to answer the question of whether the mutation (D614G) occurs due to positive selection or not.
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spelling pubmed-84080192021-09-01 D614G mutation eventuates in all VOI and VOC in SARS-CoV-2: Is it part of the positive selection pioneered by Darwin? Chakraborty, Chiranjib Saha, Abinit Sharma, Ashish Ranjan Bhattacharya, Manojit Lee, Sang-Soo Agoramoorthy, Govindasamy Mol Ther Nucleic Acids Editorial Recently, several emerging variants of SARS-CoV-2 have originated from the Wuhan strain and spread throughout the globe within one and a half years. One mutation, D614G, is very prominent in all VOI and VOC in SARS-CoV-2. This mutation might help to increase the viral fitness in all emerging variants where the mutation is present. With the help of this mutation (D614G), the SARS-CoV-2 variants have gained viral fitness to enhance viral replication and increase transmission. This paper attempts to answer the question of whether the mutation (D614G) occurs due to positive selection or not. American Society of Gene & Cell Therapy 2021-09-01 /pmc/articles/PMC8408019/ /pubmed/34484868 http://dx.doi.org/10.1016/j.omtn.2021.07.011 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Editorial
Chakraborty, Chiranjib
Saha, Abinit
Sharma, Ashish Ranjan
Bhattacharya, Manojit
Lee, Sang-Soo
Agoramoorthy, Govindasamy
D614G mutation eventuates in all VOI and VOC in SARS-CoV-2: Is it part of the positive selection pioneered by Darwin?
title D614G mutation eventuates in all VOI and VOC in SARS-CoV-2: Is it part of the positive selection pioneered by Darwin?
title_full D614G mutation eventuates in all VOI and VOC in SARS-CoV-2: Is it part of the positive selection pioneered by Darwin?
title_fullStr D614G mutation eventuates in all VOI and VOC in SARS-CoV-2: Is it part of the positive selection pioneered by Darwin?
title_full_unstemmed D614G mutation eventuates in all VOI and VOC in SARS-CoV-2: Is it part of the positive selection pioneered by Darwin?
title_short D614G mutation eventuates in all VOI and VOC in SARS-CoV-2: Is it part of the positive selection pioneered by Darwin?
title_sort d614g mutation eventuates in all voi and voc in sars-cov-2: is it part of the positive selection pioneered by darwin?
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408019/
https://www.ncbi.nlm.nih.gov/pubmed/34484868
http://dx.doi.org/10.1016/j.omtn.2021.07.011
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