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Evaluation of latent tuberculosis infection in liver transplant recipients
BACKGROUND AND OBJECTIVES: Tuberculosis is one of the main reasons for mortality in liver transplant recipients. Since Iran is considered as a tuberculosis-endemic country, the present study aims to evaluate the outcome of latent tuberculosis infection in transplant recipients after liver transplant...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tehran University of Medical Sciences
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408033/ https://www.ncbi.nlm.nih.gov/pubmed/34540155 http://dx.doi.org/10.18502/ijm.v13i2.5981 |
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author | Ahmadinejad, Zahra Mokhtaryan, Maryam Salami, Arezoo Talebian, Monavar Irajian, Hamideh Ghiasvand, Fereshteh |
author_facet | Ahmadinejad, Zahra Mokhtaryan, Maryam Salami, Arezoo Talebian, Monavar Irajian, Hamideh Ghiasvand, Fereshteh |
author_sort | Ahmadinejad, Zahra |
collection | PubMed |
description | BACKGROUND AND OBJECTIVES: Tuberculosis is one of the main reasons for mortality in liver transplant recipients. Since Iran is considered as a tuberculosis-endemic country, the present study aims to evaluate the outcome of latent tuberculosis infection in transplant recipients after liver transplantation. MATERIALS AND METHODS: The present analytical cross-sectional study was performed on transplanted patients in Imam Khomeini Complex Hospital in Tehran Iran from 2006 to 2016. All patients with positive tuberculin skin test were enrolled. Variables including demographic information, therapeutic and outcome data were gathered and analyzed. RESULTS: Among 675 transplant recipients, 100 patients had positive tuberculin skin test (14.8%). Sixty seven percent of recipients were men and the mean age was 72.67 ± 1.3 years. All patients’ received Isoniazid prophylaxis before transplantation. The mean duration of anti-tuberculosis prophylaxis before and after transplant were 2.7 ± 1.9 and 3.6 ± 5.5 months, respectively. Tuberculosis has not been occurred in none of these patients after a mean follow up time of 45.21 ± 3 months. During the study period, four subjects infected by Mycobacterium tuberculosis, while their skin test was negative before transplant. CONCLUSION: According to our study, tuberculin skin test is a reliable and sensitive test for diagnosis of latent tuberculosis in liver transplant candidates. Isoniazid prophylaxis is well tolerated in patients with end stage liver diseases and liver transplant recipients. |
format | Online Article Text |
id | pubmed-8408033 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Tehran University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-84080332021-09-16 Evaluation of latent tuberculosis infection in liver transplant recipients Ahmadinejad, Zahra Mokhtaryan, Maryam Salami, Arezoo Talebian, Monavar Irajian, Hamideh Ghiasvand, Fereshteh Iran J Microbiol Original Article BACKGROUND AND OBJECTIVES: Tuberculosis is one of the main reasons for mortality in liver transplant recipients. Since Iran is considered as a tuberculosis-endemic country, the present study aims to evaluate the outcome of latent tuberculosis infection in transplant recipients after liver transplantation. MATERIALS AND METHODS: The present analytical cross-sectional study was performed on transplanted patients in Imam Khomeini Complex Hospital in Tehran Iran from 2006 to 2016. All patients with positive tuberculin skin test were enrolled. Variables including demographic information, therapeutic and outcome data were gathered and analyzed. RESULTS: Among 675 transplant recipients, 100 patients had positive tuberculin skin test (14.8%). Sixty seven percent of recipients were men and the mean age was 72.67 ± 1.3 years. All patients’ received Isoniazid prophylaxis before transplantation. The mean duration of anti-tuberculosis prophylaxis before and after transplant were 2.7 ± 1.9 and 3.6 ± 5.5 months, respectively. Tuberculosis has not been occurred in none of these patients after a mean follow up time of 45.21 ± 3 months. During the study period, four subjects infected by Mycobacterium tuberculosis, while their skin test was negative before transplant. CONCLUSION: According to our study, tuberculin skin test is a reliable and sensitive test for diagnosis of latent tuberculosis in liver transplant candidates. Isoniazid prophylaxis is well tolerated in patients with end stage liver diseases and liver transplant recipients. Tehran University of Medical Sciences 2021-04 /pmc/articles/PMC8408033/ /pubmed/34540155 http://dx.doi.org/10.18502/ijm.v13i2.5981 Text en Copyright © 2021 The Authors. Published by Tehran University of Medical Sciences https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited. |
spellingShingle | Original Article Ahmadinejad, Zahra Mokhtaryan, Maryam Salami, Arezoo Talebian, Monavar Irajian, Hamideh Ghiasvand, Fereshteh Evaluation of latent tuberculosis infection in liver transplant recipients |
title | Evaluation of latent tuberculosis infection in liver transplant recipients |
title_full | Evaluation of latent tuberculosis infection in liver transplant recipients |
title_fullStr | Evaluation of latent tuberculosis infection in liver transplant recipients |
title_full_unstemmed | Evaluation of latent tuberculosis infection in liver transplant recipients |
title_short | Evaluation of latent tuberculosis infection in liver transplant recipients |
title_sort | evaluation of latent tuberculosis infection in liver transplant recipients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408033/ https://www.ncbi.nlm.nih.gov/pubmed/34540155 http://dx.doi.org/10.18502/ijm.v13i2.5981 |
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