Research progress, challenges and perspectives on PNPLA3 and its variants in Liver Diseases

The human patatin-like phospholipase domain-containing 3 gene (PNPLA3) is highly expressed in liver and adipose tissue and encodes a transmembrane polypeptide chain containing 481 amino acids. The I148M variant of PNPLA3 is a single nucleotide polymorphism, which is related to a variety of liver and...

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Detalles Bibliográficos
Autores principales: Xiang, Hongjiao, Wu, Zecheng, Wang, Junmin, Wu, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408107/
https://www.ncbi.nlm.nih.gov/pubmed/34476007
http://dx.doi.org/10.7150/jca.57951
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author Xiang, Hongjiao
Wu, Zecheng
Wang, Junmin
Wu, Tao
author_facet Xiang, Hongjiao
Wu, Zecheng
Wang, Junmin
Wu, Tao
author_sort Xiang, Hongjiao
collection PubMed
description The human patatin-like phospholipase domain-containing 3 gene (PNPLA3) is highly expressed in liver and adipose tissue and encodes a transmembrane polypeptide chain containing 481 amino acids. The I148M variant of PNPLA3 is a single nucleotide polymorphism, which is related to a variety of liver and cardiovascular diseases and their complications (such as non-alcoholic fatty liver disease, liver fibrosis, coronary artery disease). This review mainly describes the pathophysiological effects of PNPLA3 and its variants, and their roles in the progression of liver disease and its complications.
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spelling pubmed-84081072021-09-01 Research progress, challenges and perspectives on PNPLA3 and its variants in Liver Diseases Xiang, Hongjiao Wu, Zecheng Wang, Junmin Wu, Tao J Cancer Review The human patatin-like phospholipase domain-containing 3 gene (PNPLA3) is highly expressed in liver and adipose tissue and encodes a transmembrane polypeptide chain containing 481 amino acids. The I148M variant of PNPLA3 is a single nucleotide polymorphism, which is related to a variety of liver and cardiovascular diseases and their complications (such as non-alcoholic fatty liver disease, liver fibrosis, coronary artery disease). This review mainly describes the pathophysiological effects of PNPLA3 and its variants, and their roles in the progression of liver disease and its complications. Ivyspring International Publisher 2021-08-13 /pmc/articles/PMC8408107/ /pubmed/34476007 http://dx.doi.org/10.7150/jca.57951 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Xiang, Hongjiao
Wu, Zecheng
Wang, Junmin
Wu, Tao
Research progress, challenges and perspectives on PNPLA3 and its variants in Liver Diseases
title Research progress, challenges and perspectives on PNPLA3 and its variants in Liver Diseases
title_full Research progress, challenges and perspectives on PNPLA3 and its variants in Liver Diseases
title_fullStr Research progress, challenges and perspectives on PNPLA3 and its variants in Liver Diseases
title_full_unstemmed Research progress, challenges and perspectives on PNPLA3 and its variants in Liver Diseases
title_short Research progress, challenges and perspectives on PNPLA3 and its variants in Liver Diseases
title_sort research progress, challenges and perspectives on pnpla3 and its variants in liver diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408107/
https://www.ncbi.nlm.nih.gov/pubmed/34476007
http://dx.doi.org/10.7150/jca.57951
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AT wangjunmin researchprogresschallengesandperspectivesonpnpla3anditsvariantsinliverdiseases
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