ATG4D is the main ATG8 delipidating enzyme in mammalian cells and protects against cerebellar neurodegeneration

Despite the great advances in autophagy research in the last years, the specific functions of the four mammalian Atg4 proteases (ATG4A-D) remain unclear. In yeast, Atg4 mediates both Atg8 proteolytic activation, and its delipidation. However, it is not clear how these two roles are distributed along...

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Detalles Bibliográficos
Autores principales: Tamargo-Gómez, Isaac, Martínez-García, Gemma G., Suárez, María F., Rey, Verónica, Fueyo, Antonio, Codina-Martínez, Helena, Bretones, Gabriel, Caravia, Xurde M., Morel, Etienne, Dupont, Nicolas, Cabo, Roberto, Tomás-Zapico, Cristina, Souquere, Sylvie, Pierron, Gerard, Codogno, Patrice, López-Otín, Carlos, Fernández, Álvaro F., Mariño, Guillermo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408152/
https://www.ncbi.nlm.nih.gov/pubmed/33795848
http://dx.doi.org/10.1038/s41418-021-00776-1

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