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Risk-factors for re-admission and outcome of patients hospitalized with confirmed COVID-19

Burden of COVID-19 on Hospitals across the globe is enormous and has clinical and economic implications. In this retrospective study including consecutive adult patients with confirmed SARS-CoV-2 who were admitted between 3/2020 and 30/9/20, we aimed to identify post-discharge outcomes and risk fact...

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Autores principales: Green, Hefziba, Yahav, Dafna, Eliakim-Raz, Noa, Karny-Epstein, Nitzan, Kushnir, Shiri, Shochat, Tzippy, Tadmor, Boaz, Grossman, Alon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408195/
https://www.ncbi.nlm.nih.gov/pubmed/34465827
http://dx.doi.org/10.1038/s41598-021-96716-7
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author Green, Hefziba
Yahav, Dafna
Eliakim-Raz, Noa
Karny-Epstein, Nitzan
Kushnir, Shiri
Shochat, Tzippy
Tadmor, Boaz
Grossman, Alon
author_facet Green, Hefziba
Yahav, Dafna
Eliakim-Raz, Noa
Karny-Epstein, Nitzan
Kushnir, Shiri
Shochat, Tzippy
Tadmor, Boaz
Grossman, Alon
author_sort Green, Hefziba
collection PubMed
description Burden of COVID-19 on Hospitals across the globe is enormous and has clinical and economic implications. In this retrospective study including consecutive adult patients with confirmed SARS-CoV-2 who were admitted between 3/2020 and 30/9/20, we aimed to identify post-discharge outcomes and risk factors for re-admission among COVID-19 hospitalized patients. Mortality and re-admissions were documented for a median post discharge follow up of 59 days (interquartile range 28,161). Univariate and multivariate analyses of risk factors for re-admission were performed. Overall, 618 hospitalized COVID-19 patients were included. Of the 544 patient who were discharged, 10 patients (1.83%) died following discharge and 50 patients (9.2%) were re-admitted. Median time to re-admission was 7 days (interquartile range 3, 24). Oxygen saturation or treatment prior to discharge were not associated with re-admissions. Risk factors for re-admission in multivariate analysis included solid organ transplantation (hazard ratio [HR] 3.37, 95% confidence interval [CI] 2.73–7.5, p = 0.0028) and higher Charlson comorbidity index (HR 1.34, 95% CI 1.23–1.46, p < 0.0001). Mean age of post discharge mortality cases was 85.0 (SD 9.98), 80% of them had cognitive decline or needed help in ADL at baseline. In conclusion, re-admission rates of hospitalized COVID-19 are fairly moderate. Predictors of re-admission are non-modifiable, including baseline comorbidities, rather than COVID-19 severity or treatment.
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spelling pubmed-84081952021-09-01 Risk-factors for re-admission and outcome of patients hospitalized with confirmed COVID-19 Green, Hefziba Yahav, Dafna Eliakim-Raz, Noa Karny-Epstein, Nitzan Kushnir, Shiri Shochat, Tzippy Tadmor, Boaz Grossman, Alon Sci Rep Article Burden of COVID-19 on Hospitals across the globe is enormous and has clinical and economic implications. In this retrospective study including consecutive adult patients with confirmed SARS-CoV-2 who were admitted between 3/2020 and 30/9/20, we aimed to identify post-discharge outcomes and risk factors for re-admission among COVID-19 hospitalized patients. Mortality and re-admissions were documented for a median post discharge follow up of 59 days (interquartile range 28,161). Univariate and multivariate analyses of risk factors for re-admission were performed. Overall, 618 hospitalized COVID-19 patients were included. Of the 544 patient who were discharged, 10 patients (1.83%) died following discharge and 50 patients (9.2%) were re-admitted. Median time to re-admission was 7 days (interquartile range 3, 24). Oxygen saturation or treatment prior to discharge were not associated with re-admissions. Risk factors for re-admission in multivariate analysis included solid organ transplantation (hazard ratio [HR] 3.37, 95% confidence interval [CI] 2.73–7.5, p = 0.0028) and higher Charlson comorbidity index (HR 1.34, 95% CI 1.23–1.46, p < 0.0001). Mean age of post discharge mortality cases was 85.0 (SD 9.98), 80% of them had cognitive decline or needed help in ADL at baseline. In conclusion, re-admission rates of hospitalized COVID-19 are fairly moderate. Predictors of re-admission are non-modifiable, including baseline comorbidities, rather than COVID-19 severity or treatment. Nature Publishing Group UK 2021-08-31 /pmc/articles/PMC8408195/ /pubmed/34465827 http://dx.doi.org/10.1038/s41598-021-96716-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Green, Hefziba
Yahav, Dafna
Eliakim-Raz, Noa
Karny-Epstein, Nitzan
Kushnir, Shiri
Shochat, Tzippy
Tadmor, Boaz
Grossman, Alon
Risk-factors for re-admission and outcome of patients hospitalized with confirmed COVID-19
title Risk-factors for re-admission and outcome of patients hospitalized with confirmed COVID-19
title_full Risk-factors for re-admission and outcome of patients hospitalized with confirmed COVID-19
title_fullStr Risk-factors for re-admission and outcome of patients hospitalized with confirmed COVID-19
title_full_unstemmed Risk-factors for re-admission and outcome of patients hospitalized with confirmed COVID-19
title_short Risk-factors for re-admission and outcome of patients hospitalized with confirmed COVID-19
title_sort risk-factors for re-admission and outcome of patients hospitalized with confirmed covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408195/
https://www.ncbi.nlm.nih.gov/pubmed/34465827
http://dx.doi.org/10.1038/s41598-021-96716-7
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