Trans-ethnic genome-wide association study of severe COVID-19

COVID-19 has caused numerous infections with diverse clinical symptoms. To identify human genetic variants contributing to the clinical development of COVID-19, we genotyped 1457 (598/859 with severe/mild symptoms) and sequenced 1141 (severe/mild: 474/667) patients of Chinese ancestry. We further in...

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Detalles Bibliográficos
Autores principales: Wu, Peng, Ding, Lin, Li, Xiaodong, Liu, Siyang, Cheng, Fanjun, He, Qing, Xiao, Mingzhong, Wu, Ping, Hou, Hongyan, Jiang, Minghui, Long, Pinpin, Wang, Hao, Liu, Linlin, Qu, Minghan, Shi, Xian, Jiang, Qin, Mo, Tingting, Ding, Wencheng, Fu, Yu, Han, Shi, Huo, Xixiang, Zeng, Yingchun, Zhou, Yana, Zhang, Qing, Ke, Jia, Xu, Xi, Ni, Wei, Shao, Zuoyu, Wang, Jingzhi, Liu, Panhong, Li, Zilong, Jin, Yan, Zheng, Fang, Wang, Fang, Liu, Lei, Li, Wending, Liu, Kang, Peng, Rong, Xu, Xuedan, Lin, Yuhui, Gao, Hui, Shi, Limei, Geng, Ziyue, Mu, Xuanwen, Yan, Yu, Wang, Kai, Wu, Degang, Hao, Xingjie, Cheng, Shanshan, Qiu, Gaokun, Guo, Huan, Li, Kezhen, Chen, Gang, Sun, Ziyong, Lin, Xihong, Jin, Xin, Wang, Feng, Sun, Chaoyang, Wang, Chaolong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408224/
https://www.ncbi.nlm.nih.gov/pubmed/34465887
http://dx.doi.org/10.1038/s42003-021-02549-5
Descripción
Sumario:COVID-19 has caused numerous infections with diverse clinical symptoms. To identify human genetic variants contributing to the clinical development of COVID-19, we genotyped 1457 (598/859 with severe/mild symptoms) and sequenced 1141 (severe/mild: 474/667) patients of Chinese ancestry. We further incorporated 1401 genotyped and 948 sequenced ancestry-matched population controls, and tested genome-wide association on 1072 severe cases versus 3875 mild or population controls, followed by trans-ethnic meta-analysis with summary statistics of 3199 hospitalized cases and 897,488 population controls from the COVID-19 Host Genetics Initiative. We identified three significant signals outside the well-established 3p21.31 locus: an intronic variant in FOXP4-AS1 (rs1853837, odds ratio OR = 1.28, P = 2.51 × 10(−10), allele frequencies in Chinese/European AF = 0.345/0.105), a frameshift insertion in ABO (rs8176719, OR = 1.19, P = 8.98 × 10(−9), AF = 0.422/0.395) and a Chinese-specific intronic variant in MEF2B (rs74490654, OR = 8.73, P = 1.22 × 10(−8), AF = 0.004/0). These findings highlight an important role of the adaptive immunity and the ABO blood-group system in protection from developing severe COVID-19.

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