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Genetic regulation of spermine oxidase activity and cancer risk: a Mendelian randomization study

Spermine oxidase (SMOX) catalyzes the oxidation of spermine to spermidine. Observational studies have reported SMOX as a source of reactive oxygen species associated with cancer, implying that inhibition of SMOX could be a target for chemoprevention. Here we test causality of SMOX levels with cancer...

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Detalles Bibliográficos
Autores principales:	Fadista, João, Yakimov, Victor, Võsa, Urmo, Hansen, Christine S., Kasela, Silva, Skotte, Line, Geller, Frank, Courraud, Julie, Esko, Tõnu, Kukuškina, Viktorija, Buil, Alfonso, Melbye, Mads, Werge, Thomas M., Hougaard, David M., Milani, Lili, Bybjerg-Grauholm, Jonas, Cohen, Arieh S., Feenstra, Bjarke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408253/ https://www.ncbi.nlm.nih.gov/pubmed/34465810 http://dx.doi.org/10.1038/s41598-021-97069-x

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