Histopathological, immunohistochemical and molecular biologic study of an enucleated specimen of a case of Eales’ disease

Eales’ disease is a retinal vasculitis characterized by retinal inflammation, ischemia, and neovascularization. Exact pathogenesis of this disease is yet to be found out. We present a 29-year-old male, diagnosed with Eales’ disease in both eyes with persistent intraocular inflammation. Enucleation o...

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Autores principales: Shah, Amravi, Giridhar, Sneha, Patnaik, Gazal, Mhatre, Radhika, Das, Dipankar, Janani, M. K., Mahadevan, Anita, Biswas, Jyotirmay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408300/
https://www.ncbi.nlm.nih.gov/pubmed/34467418
http://dx.doi.org/10.1186/s12348-021-00259-x
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author Shah, Amravi
Giridhar, Sneha
Patnaik, Gazal
Mhatre, Radhika
Das, Dipankar
Janani, M. K.
Mahadevan, Anita
Biswas, Jyotirmay
author_facet Shah, Amravi
Giridhar, Sneha
Patnaik, Gazal
Mhatre, Radhika
Das, Dipankar
Janani, M. K.
Mahadevan, Anita
Biswas, Jyotirmay
author_sort Shah, Amravi
collection PubMed
description Eales’ disease is a retinal vasculitis characterized by retinal inflammation, ischemia, and neovascularization. Exact pathogenesis of this disease is yet to be found out. We present a 29-year-old male, diagnosed with Eales’ disease in both eyes with persistent intraocular inflammation. Enucleation of the pthisical right eye was subjected for histopathological examination immunohistochemistry and molecular biologic study for mycobacterial tuberculosis DNA. Our study showed that Eales disease is probably a T cell mediated disease which is triggered by mycobacterial TB DNA. Further studies are needed to confirm our findings.
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spelling pubmed-84083002021-09-16 Histopathological, immunohistochemical and molecular biologic study of an enucleated specimen of a case of Eales’ disease Shah, Amravi Giridhar, Sneha Patnaik, Gazal Mhatre, Radhika Das, Dipankar Janani, M. K. Mahadevan, Anita Biswas, Jyotirmay J Ophthalmic Inflamm Infect Brief Report Eales’ disease is a retinal vasculitis characterized by retinal inflammation, ischemia, and neovascularization. Exact pathogenesis of this disease is yet to be found out. We present a 29-year-old male, diagnosed with Eales’ disease in both eyes with persistent intraocular inflammation. Enucleation of the pthisical right eye was subjected for histopathological examination immunohistochemistry and molecular biologic study for mycobacterial tuberculosis DNA. Our study showed that Eales disease is probably a T cell mediated disease which is triggered by mycobacterial TB DNA. Further studies are needed to confirm our findings. Springer Berlin Heidelberg 2021-09-01 /pmc/articles/PMC8408300/ /pubmed/34467418 http://dx.doi.org/10.1186/s12348-021-00259-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Report
Shah, Amravi
Giridhar, Sneha
Patnaik, Gazal
Mhatre, Radhika
Das, Dipankar
Janani, M. K.
Mahadevan, Anita
Biswas, Jyotirmay
Histopathological, immunohistochemical and molecular biologic study of an enucleated specimen of a case of Eales’ disease
title Histopathological, immunohistochemical and molecular biologic study of an enucleated specimen of a case of Eales’ disease
title_full Histopathological, immunohistochemical and molecular biologic study of an enucleated specimen of a case of Eales’ disease
title_fullStr Histopathological, immunohistochemical and molecular biologic study of an enucleated specimen of a case of Eales’ disease
title_full_unstemmed Histopathological, immunohistochemical and molecular biologic study of an enucleated specimen of a case of Eales’ disease
title_short Histopathological, immunohistochemical and molecular biologic study of an enucleated specimen of a case of Eales’ disease
title_sort histopathological, immunohistochemical and molecular biologic study of an enucleated specimen of a case of eales’ disease
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408300/
https://www.ncbi.nlm.nih.gov/pubmed/34467418
http://dx.doi.org/10.1186/s12348-021-00259-x
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