SARS-CoV-2-specific T cells in infection and vaccination

During viral infections, antibodies and T cells act together to prevent pathogen spread and remove virus-infected cells. Virus-specific adaptive immunity can, however, also trigger pathological processes characterized by localized or systemic inflammatory events. The protective and/or pathological r...

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Autores principales: Bertoletti, Antonio, Le Bert, Nina, Qui, Martin, Tan, Anthony T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408362/
https://www.ncbi.nlm.nih.gov/pubmed/34471260
http://dx.doi.org/10.1038/s41423-021-00743-3
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author Bertoletti, Antonio
Le Bert, Nina
Qui, Martin
Tan, Anthony T.
author_facet Bertoletti, Antonio
Le Bert, Nina
Qui, Martin
Tan, Anthony T.
author_sort Bertoletti, Antonio
collection PubMed
description During viral infections, antibodies and T cells act together to prevent pathogen spread and remove virus-infected cells. Virus-specific adaptive immunity can, however, also trigger pathological processes characterized by localized or systemic inflammatory events. The protective and/or pathological role of virus-specific T cells in SARS-CoV-2 infection has been the focus of many studies in COVID-19 patients and in vaccinated individuals. Here, we review the works that have elucidated the function of SARS-CoV-2-specific T cells in patients and in vaccinated individuals. Understanding whether SARS-CoV-2-specific T cells are more linked to protection or pathogenesis is pivotal to define future therapeutic and prophylactic strategies to manage the current pandemic.
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spelling pubmed-84083622021-09-01 SARS-CoV-2-specific T cells in infection and vaccination Bertoletti, Antonio Le Bert, Nina Qui, Martin Tan, Anthony T. Cell Mol Immunol Review Article During viral infections, antibodies and T cells act together to prevent pathogen spread and remove virus-infected cells. Virus-specific adaptive immunity can, however, also trigger pathological processes characterized by localized or systemic inflammatory events. The protective and/or pathological role of virus-specific T cells in SARS-CoV-2 infection has been the focus of many studies in COVID-19 patients and in vaccinated individuals. Here, we review the works that have elucidated the function of SARS-CoV-2-specific T cells in patients and in vaccinated individuals. Understanding whether SARS-CoV-2-specific T cells are more linked to protection or pathogenesis is pivotal to define future therapeutic and prophylactic strategies to manage the current pandemic. Nature Publishing Group UK 2021-09-01 2021-10 /pmc/articles/PMC8408362/ /pubmed/34471260 http://dx.doi.org/10.1038/s41423-021-00743-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Bertoletti, Antonio
Le Bert, Nina
Qui, Martin
Tan, Anthony T.
SARS-CoV-2-specific T cells in infection and vaccination
title SARS-CoV-2-specific T cells in infection and vaccination
title_full SARS-CoV-2-specific T cells in infection and vaccination
title_fullStr SARS-CoV-2-specific T cells in infection and vaccination
title_full_unstemmed SARS-CoV-2-specific T cells in infection and vaccination
title_short SARS-CoV-2-specific T cells in infection and vaccination
title_sort sars-cov-2-specific t cells in infection and vaccination
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408362/
https://www.ncbi.nlm.nih.gov/pubmed/34471260
http://dx.doi.org/10.1038/s41423-021-00743-3
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