Analyzing the Possibility of Utilizing CBCT Radiomics as an Independent Modality: A Phantom Study

AIM: To verify if computed tomography (CT) radiomics were reproducible by cone beam CT (CBCT) radiomics by using Catphan(®) 504. MATERIALS AND METHODS: Catphan(®) 504 was imaged using the default IGRT OBI CBCT imaging protocols and CT scanner. Seven known density image regions of the phantom were segmented and image feature was extracted by Imaging Biomarker Explorer (IBEX) software. The 49 selected features from four feature categories were analyzed by considering each region of interest (ROI) segment as individual image set. Correlation was studies using interclass correlation coefficient (ICC) and Pearson’s correlation coefficient. RESULTS: The ICC of the three feature categories, namely intensity, GLCM, and GLRLM was significant (p-value<0.05) in comparison with CT, while the ICC of the fourth feature category, NID, was no significant. The average absolute Pearson’s correlation coefficient from the features of the images was as follows: CT: r=0.679±0.257, CBC(Thead): r=0.707±0.231, CBCT(thorax): r=0.643±0.260, and CBCT(pelvis): r=0.594±0.276. CONCLUSION: It seems that the various densities of Catphan(® )504 ROI image segments of the CT radiomics are reproducible with CBCT radiomics and CBCT radiomics can be used as an independent modality.