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Cross-species higher sensitivities of FcγRIIIA/FcγRIV to afucosylated IgG for enhanced ADCC

BACKGROUND: Expressing afucosylated human IgG1 antibodies with Chinese hamster ovary (CHO) cells deficient of α-(1,6)-fucosyltransferase (FUT8) is being more and more accepted as a routine method to enhance antibody-dependent cellular cytotoxicity (ADCC) of therapeutic antibodies, especially for ant...

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Detalles Bibliográficos
Autores principales:	Mao, Changchuin, Near, Richard, Zhong, Xuemei, Gao, Wenda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408537/ https://www.ncbi.nlm.nih.gov/pubmed/34485821 http://dx.doi.org/10.1093/abt/tbab016

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