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Ethnicity, pre-existing comorbidities, and outcomes of hospitalised patients with COVID-19

Background: The coronavirus disease 2019 (COVID-19) pandemic has resulted in thousands of deaths in the UK. Those with existing comorbidities and minority ethnic groups have been found to be at increased risk of mortality. We wished to determine if there were any differences in intensive care unit (...

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Autores principales: Santorelli, Gillian, McCooe, Michael, Sheldon, Trevor A., Wright, John, Lawton, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408538/
https://www.ncbi.nlm.nih.gov/pubmed/34522788
http://dx.doi.org/10.12688/wellcomeopenres.16580.2
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author Santorelli, Gillian
McCooe, Michael
Sheldon, Trevor A.
Wright, John
Lawton, Tom
author_facet Santorelli, Gillian
McCooe, Michael
Sheldon, Trevor A.
Wright, John
Lawton, Tom
author_sort Santorelli, Gillian
collection PubMed
description Background: The coronavirus disease 2019 (COVID-19) pandemic has resulted in thousands of deaths in the UK. Those with existing comorbidities and minority ethnic groups have been found to be at increased risk of mortality. We wished to determine if there were any differences in intensive care unit (ICU) admission and 30-day hospital mortality in a city with high levels of deprivation and a large community of people of South Asian heritage.  Methods: Detailed information on 582 COVID-19-positive inpatients in Bradford and Calderdale between February-August 2020 were extracted from Electronic Health Records. Logistic regression and Cox proportional hazards models were used to explore the relationship between ethnicity with admission to ICU and 30-day mortality, respectively accounting for the effect of demographic and clinical confounders. Results: The sample consisted of 408 (70%) White, 142 (24%) South Asian and 32 (6%) other minority ethnic patients. Ethnic minority patients were younger, more likely to live in deprived areas, and be overweight/obese, have type 2 diabetes, hypertension and asthma compared to white patients, but were less likely to have cancer (South Asian patients only) and COPD. Male and obese patients were more likely to be admitted to ICU, and patients of South Asian ethnicity, older age, and those with cancer were less likely. Being male, older age, deprivation, obesity, and cancer were associated with 30-day mortality. The risk of death in South Asian patients was the same as in white patients HR 1.03 (0.58, 1.82). Conclusions: Despite South Asian patients being less likely to be admitted to ICU and having a higher prevalence of diabetes and obesity, there was no difference in the risk of death compared to white patients. This contrasts with other findings and highlights the value of studies of communities which may have different ethnic, deprivation and clinical risk profiles.
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spelling pubmed-84085382021-09-13 Ethnicity, pre-existing comorbidities, and outcomes of hospitalised patients with COVID-19 Santorelli, Gillian McCooe, Michael Sheldon, Trevor A. Wright, John Lawton, Tom Wellcome Open Res Research Article Background: The coronavirus disease 2019 (COVID-19) pandemic has resulted in thousands of deaths in the UK. Those with existing comorbidities and minority ethnic groups have been found to be at increased risk of mortality. We wished to determine if there were any differences in intensive care unit (ICU) admission and 30-day hospital mortality in a city with high levels of deprivation and a large community of people of South Asian heritage.  Methods: Detailed information on 582 COVID-19-positive inpatients in Bradford and Calderdale between February-August 2020 were extracted from Electronic Health Records. Logistic regression and Cox proportional hazards models were used to explore the relationship between ethnicity with admission to ICU and 30-day mortality, respectively accounting for the effect of demographic and clinical confounders. Results: The sample consisted of 408 (70%) White, 142 (24%) South Asian and 32 (6%) other minority ethnic patients. Ethnic minority patients were younger, more likely to live in deprived areas, and be overweight/obese, have type 2 diabetes, hypertension and asthma compared to white patients, but were less likely to have cancer (South Asian patients only) and COPD. Male and obese patients were more likely to be admitted to ICU, and patients of South Asian ethnicity, older age, and those with cancer were less likely. Being male, older age, deprivation, obesity, and cancer were associated with 30-day mortality. The risk of death in South Asian patients was the same as in white patients HR 1.03 (0.58, 1.82). Conclusions: Despite South Asian patients being less likely to be admitted to ICU and having a higher prevalence of diabetes and obesity, there was no difference in the risk of death compared to white patients. This contrasts with other findings and highlights the value of studies of communities which may have different ethnic, deprivation and clinical risk profiles. F1000 Research Limited 2021-06-30 /pmc/articles/PMC8408538/ /pubmed/34522788 http://dx.doi.org/10.12688/wellcomeopenres.16580.2 Text en Copyright: © 2021 Santorelli G et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Santorelli, Gillian
McCooe, Michael
Sheldon, Trevor A.
Wright, John
Lawton, Tom
Ethnicity, pre-existing comorbidities, and outcomes of hospitalised patients with COVID-19
title Ethnicity, pre-existing comorbidities, and outcomes of hospitalised patients with COVID-19
title_full Ethnicity, pre-existing comorbidities, and outcomes of hospitalised patients with COVID-19
title_fullStr Ethnicity, pre-existing comorbidities, and outcomes of hospitalised patients with COVID-19
title_full_unstemmed Ethnicity, pre-existing comorbidities, and outcomes of hospitalised patients with COVID-19
title_short Ethnicity, pre-existing comorbidities, and outcomes of hospitalised patients with COVID-19
title_sort ethnicity, pre-existing comorbidities, and outcomes of hospitalised patients with covid-19
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408538/
https://www.ncbi.nlm.nih.gov/pubmed/34522788
http://dx.doi.org/10.12688/wellcomeopenres.16580.2
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