TIMELESS‐TIPIN and UBXN‐3 promote replisome disassembly during DNA replication termination in Caenorhabditis elegans

The eukaryotic replisome is rapidly disassembled during DNA replication termination. In metazoa, the cullin‐RING ubiquitin ligase CUL‐2(LRR‐1) drives ubiquitylation of the CMG helicase, leading to replisome disassembly by the p97/CDC‐48 “unfoldase”. Here, we combine in vitro reconstitution with in v...

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Detalles Bibliográficos
Autores principales: Xia, Yisui, Fujisawa, Ryo, Deegan, Tom D, Sonneville, Remi, Labib, Karim P M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408604/
https://www.ncbi.nlm.nih.gov/pubmed/34269473
http://dx.doi.org/10.15252/embj.2021108053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408604/
https://www.ncbi.nlm.nih.gov/pubmed/34269473
http://dx.doi.org/10.15252/embj.2021108053

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