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Carbon-ion radiotherapy in osteosarcoma of the mandible: a case report

Carbon-ion radiotherapy (CIRT) is on the rise as a treatment choice for malignant tumor. Compared to conventional radiotherapy, particle beams have different physical and biological properties. Particle beam provides a low entry dose, deposits most of the energy at the endpoint of the flight path, a...

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Autores principales: Ha, Tae-Wook, Park, Slmaro, Youn, Min Yeong, Kim, Dong Wook, Kim, Hyung Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Oral and Maxillofacial Surgeons 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408645/
https://www.ncbi.nlm.nih.gov/pubmed/34462388
http://dx.doi.org/10.5125/jkaoms.2021.47.4.315
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author Ha, Tae-Wook
Park, Slmaro
Youn, Min Yeong
Kim, Dong Wook
Kim, Hyung Jun
author_facet Ha, Tae-Wook
Park, Slmaro
Youn, Min Yeong
Kim, Dong Wook
Kim, Hyung Jun
author_sort Ha, Tae-Wook
collection PubMed
description Carbon-ion radiotherapy (CIRT) is on the rise as a treatment choice for malignant tumor. Compared to conventional radiotherapy, particle beams have different physical and biological properties. Particle beam provides a low entry dose, deposits most of the energy at the endpoint of the flight path, and forms an asymptotic dose peak (the “Bragg peak”). Compared to protons, carbon with its larger mass decreases beam scattering, resulting in a sharper dose distribution border. We report a 50-year-old male who underwent CIRT without surgical resection on osteosarcoma of the mandible. After CIRT, the patient’s pain was gone, and the malignant mass remained stable with accompanying necrosis. Nine months later, however, magnetic resonance imaging demonstrated progression of the left mandibular osteosarcoma with pulmonary metastases. After multidisciplinary discussion, concurrent chemoradiotherapy was conducted. While necrotic bone segments came out of the mandible during subsequent periodic outpatient visits, the tumor itself was stable. Thirty months after his first visit and diagnosis, the patient is waiting for chemotherapy. Although CIRT is superior in treating radioresistant hypoxic disease, CIRT is in its infancy, so care must be taken for its indications and complications.
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spelling pubmed-84086452021-09-08 Carbon-ion radiotherapy in osteosarcoma of the mandible: a case report Ha, Tae-Wook Park, Slmaro Youn, Min Yeong Kim, Dong Wook Kim, Hyung Jun J Korean Assoc Oral Maxillofac Surg Case Report Carbon-ion radiotherapy (CIRT) is on the rise as a treatment choice for malignant tumor. Compared to conventional radiotherapy, particle beams have different physical and biological properties. Particle beam provides a low entry dose, deposits most of the energy at the endpoint of the flight path, and forms an asymptotic dose peak (the “Bragg peak”). Compared to protons, carbon with its larger mass decreases beam scattering, resulting in a sharper dose distribution border. We report a 50-year-old male who underwent CIRT without surgical resection on osteosarcoma of the mandible. After CIRT, the patient’s pain was gone, and the malignant mass remained stable with accompanying necrosis. Nine months later, however, magnetic resonance imaging demonstrated progression of the left mandibular osteosarcoma with pulmonary metastases. After multidisciplinary discussion, concurrent chemoradiotherapy was conducted. While necrotic bone segments came out of the mandible during subsequent periodic outpatient visits, the tumor itself was stable. Thirty months after his first visit and diagnosis, the patient is waiting for chemotherapy. Although CIRT is superior in treating radioresistant hypoxic disease, CIRT is in its infancy, so care must be taken for its indications and complications. The Korean Association of Oral and Maxillofacial Surgeons 2021-08-31 2021-08-31 /pmc/articles/PMC8408645/ /pubmed/34462388 http://dx.doi.org/10.5125/jkaoms.2021.47.4.315 Text en Copyright © 2021 The Korean Association of Oral and Maxillofacial Surgeons. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Ha, Tae-Wook
Park, Slmaro
Youn, Min Yeong
Kim, Dong Wook
Kim, Hyung Jun
Carbon-ion radiotherapy in osteosarcoma of the mandible: a case report
title Carbon-ion radiotherapy in osteosarcoma of the mandible: a case report
title_full Carbon-ion radiotherapy in osteosarcoma of the mandible: a case report
title_fullStr Carbon-ion radiotherapy in osteosarcoma of the mandible: a case report
title_full_unstemmed Carbon-ion radiotherapy in osteosarcoma of the mandible: a case report
title_short Carbon-ion radiotherapy in osteosarcoma of the mandible: a case report
title_sort carbon-ion radiotherapy in osteosarcoma of the mandible: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408645/
https://www.ncbi.nlm.nih.gov/pubmed/34462388
http://dx.doi.org/10.5125/jkaoms.2021.47.4.315
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