Molnupiravir Inhibits Replication of the Emerging SARS-CoV-2 Variants of Concern in a Hamster Infection Model

The emergence of SARS-CoV-2 variants of concern (VoCs) has exacerbated the COVID-19 pandemic. Currently available monoclonal antibodies and vaccines appear to have reduced efficacy against some of these VoCs. Antivirals targeting conserved proteins of SARS-CoV-2 are unlikely to be affected by mutati...

Descripción completa

Detalles Bibliográficos
Autores principales: Abdelnabi, Rana, Foo, Caroline S, De Jonghe, Steven, Maes, Piet, Weynand, Birgit, Neyts, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408768/
https://www.ncbi.nlm.nih.gov/pubmed/34244768
http://dx.doi.org/10.1093/infdis/jiab361
_version_ 1783746877531881472
author Abdelnabi, Rana
Foo, Caroline S
De Jonghe, Steven
Maes, Piet
Weynand, Birgit
Neyts, Johan
author_facet Abdelnabi, Rana
Foo, Caroline S
De Jonghe, Steven
Maes, Piet
Weynand, Birgit
Neyts, Johan
author_sort Abdelnabi, Rana
collection PubMed
description The emergence of SARS-CoV-2 variants of concern (VoCs) has exacerbated the COVID-19 pandemic. Currently available monoclonal antibodies and vaccines appear to have reduced efficacy against some of these VoCs. Antivirals targeting conserved proteins of SARS-CoV-2 are unlikely to be affected by mutations arising in VoCs and should therefore be effective against emerging variants. We here investigate the efficacy of molnupiravir, currently in phase 2 clinical trials, in hamsters infected with Wuhan strain or B.1.1.7 and B.1.351 variants. Molnupiravir proved to be effective against infections with each of the variants and therefore may have potential combating current and future emerging VoCs.
format Online
Article
Text
id pubmed-8408768
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-84087682021-09-02 Molnupiravir Inhibits Replication of the Emerging SARS-CoV-2 Variants of Concern in a Hamster Infection Model Abdelnabi, Rana Foo, Caroline S De Jonghe, Steven Maes, Piet Weynand, Birgit Neyts, Johan J Infect Dis Brief Report The emergence of SARS-CoV-2 variants of concern (VoCs) has exacerbated the COVID-19 pandemic. Currently available monoclonal antibodies and vaccines appear to have reduced efficacy against some of these VoCs. Antivirals targeting conserved proteins of SARS-CoV-2 are unlikely to be affected by mutations arising in VoCs and should therefore be effective against emerging variants. We here investigate the efficacy of molnupiravir, currently in phase 2 clinical trials, in hamsters infected with Wuhan strain or B.1.1.7 and B.1.351 variants. Molnupiravir proved to be effective against infections with each of the variants and therefore may have potential combating current and future emerging VoCs. Oxford University Press 2021-07-09 /pmc/articles/PMC8408768/ /pubmed/34244768 http://dx.doi.org/10.1093/infdis/jiab361 Text en © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Abdelnabi, Rana
Foo, Caroline S
De Jonghe, Steven
Maes, Piet
Weynand, Birgit
Neyts, Johan
Molnupiravir Inhibits Replication of the Emerging SARS-CoV-2 Variants of Concern in a Hamster Infection Model
title Molnupiravir Inhibits Replication of the Emerging SARS-CoV-2 Variants of Concern in a Hamster Infection Model
title_full Molnupiravir Inhibits Replication of the Emerging SARS-CoV-2 Variants of Concern in a Hamster Infection Model
title_fullStr Molnupiravir Inhibits Replication of the Emerging SARS-CoV-2 Variants of Concern in a Hamster Infection Model
title_full_unstemmed Molnupiravir Inhibits Replication of the Emerging SARS-CoV-2 Variants of Concern in a Hamster Infection Model
title_short Molnupiravir Inhibits Replication of the Emerging SARS-CoV-2 Variants of Concern in a Hamster Infection Model
title_sort molnupiravir inhibits replication of the emerging sars-cov-2 variants of concern in a hamster infection model
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408768/
https://www.ncbi.nlm.nih.gov/pubmed/34244768
http://dx.doi.org/10.1093/infdis/jiab361
work_keys_str_mv AT abdelnabirana molnupiravirinhibitsreplicationoftheemergingsarscov2variantsofconcerninahamsterinfectionmodel
AT foocarolines molnupiravirinhibitsreplicationoftheemergingsarscov2variantsofconcerninahamsterinfectionmodel
AT dejonghesteven molnupiravirinhibitsreplicationoftheemergingsarscov2variantsofconcerninahamsterinfectionmodel
AT maespiet molnupiravirinhibitsreplicationoftheemergingsarscov2variantsofconcerninahamsterinfectionmodel
AT weynandbirgit molnupiravirinhibitsreplicationoftheemergingsarscov2variantsofconcerninahamsterinfectionmodel
AT neytsjohan molnupiravirinhibitsreplicationoftheemergingsarscov2variantsofconcerninahamsterinfectionmodel

Ejemplares similares