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Distinguishable Targeting of Non‐Small Cell Lung Cancer Using Hyaluronan Functionalized Platinum Nanoclusters and Their Inhibition Behaviors of Proliferation, Invasion, Migration
Lung cancer is the leading cause of cancer deaths worldwide and most cancer patients receiving conventional chemotherapy suffer from severe side effects due to the non‐selective effects of chemotherapeutic drugs on normal cells. Targeted nanomaterials can obtain excellent accumulation at the tumor s...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409085/ https://www.ncbi.nlm.nih.gov/pubmed/34363352 http://dx.doi.org/10.1002/open.202100070 |
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author | Liu, Ting Huang, Xin Zhao, Lingyun Xiao, Zhongqing Li, Zengbei Xin, Yi Yang, Shanshan Guo, Di Zhao, Wenfei Mi, Yang Li, Hongyun |
author_facet | Liu, Ting Huang, Xin Zhao, Lingyun Xiao, Zhongqing Li, Zengbei Xin, Yi Yang, Shanshan Guo, Di Zhao, Wenfei Mi, Yang Li, Hongyun |
author_sort | Liu, Ting |
collection | PubMed |
description | Lung cancer is the leading cause of cancer deaths worldwide and most cancer patients receiving conventional chemotherapy suffer from severe side effects due to the non‐selective effects of chemotherapeutic drugs on normal cells. Targeted nanomaterials can obtain excellent accumulation at the tumor site through their active or passive targeting mechanisms, thereby reducing the toxicity of the drugs in various ways. In this study, hyaluronic acid (HA) which could specifically bind to CD44 on the surface of tumor cells, was used to modify amine‐caged platinum nanoclusters (Pt NCs‐NH(2)) to obtain targeting HA‐Pt NCs‐NH(2). Based on the differential expression of CD44 on the surface of three lung cells (non‐small cell lung cancer cell H1299, small cell lung cancer cell H446, and embryonic lung fibroblast HFL1), HA‐Pt NCs‐NH(2) can differentially enter the three cells and achieve their targeting of non‐small cell lung cancer cell (NSCLC) cells. Pt NCs significantly inhibited the proliferation, migration and invasion of NSCLC cells and induced their apoptosis in comparison of classical cisplatin and carboplatin, showing a bright future in early diagnosis and treatment of NSCLC. |
format | Online Article Text |
id | pubmed-8409085 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84090852021-09-03 Distinguishable Targeting of Non‐Small Cell Lung Cancer Using Hyaluronan Functionalized Platinum Nanoclusters and Their Inhibition Behaviors of Proliferation, Invasion, Migration Liu, Ting Huang, Xin Zhao, Lingyun Xiao, Zhongqing Li, Zengbei Xin, Yi Yang, Shanshan Guo, Di Zhao, Wenfei Mi, Yang Li, Hongyun ChemistryOpen Full Papers Lung cancer is the leading cause of cancer deaths worldwide and most cancer patients receiving conventional chemotherapy suffer from severe side effects due to the non‐selective effects of chemotherapeutic drugs on normal cells. Targeted nanomaterials can obtain excellent accumulation at the tumor site through their active or passive targeting mechanisms, thereby reducing the toxicity of the drugs in various ways. In this study, hyaluronic acid (HA) which could specifically bind to CD44 on the surface of tumor cells, was used to modify amine‐caged platinum nanoclusters (Pt NCs‐NH(2)) to obtain targeting HA‐Pt NCs‐NH(2). Based on the differential expression of CD44 on the surface of three lung cells (non‐small cell lung cancer cell H1299, small cell lung cancer cell H446, and embryonic lung fibroblast HFL1), HA‐Pt NCs‐NH(2) can differentially enter the three cells and achieve their targeting of non‐small cell lung cancer cell (NSCLC) cells. Pt NCs significantly inhibited the proliferation, migration and invasion of NSCLC cells and induced their apoptosis in comparison of classical cisplatin and carboplatin, showing a bright future in early diagnosis and treatment of NSCLC. John Wiley and Sons Inc. 2021-08-06 /pmc/articles/PMC8409085/ /pubmed/34363352 http://dx.doi.org/10.1002/open.202100070 Text en © 2021 The Authors. Published by Wiley-VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Full Papers Liu, Ting Huang, Xin Zhao, Lingyun Xiao, Zhongqing Li, Zengbei Xin, Yi Yang, Shanshan Guo, Di Zhao, Wenfei Mi, Yang Li, Hongyun Distinguishable Targeting of Non‐Small Cell Lung Cancer Using Hyaluronan Functionalized Platinum Nanoclusters and Their Inhibition Behaviors of Proliferation, Invasion, Migration |
title | Distinguishable Targeting of Non‐Small Cell Lung Cancer Using Hyaluronan Functionalized Platinum Nanoclusters and Their Inhibition Behaviors of Proliferation, Invasion, Migration |
title_full | Distinguishable Targeting of Non‐Small Cell Lung Cancer Using Hyaluronan Functionalized Platinum Nanoclusters and Their Inhibition Behaviors of Proliferation, Invasion, Migration |
title_fullStr | Distinguishable Targeting of Non‐Small Cell Lung Cancer Using Hyaluronan Functionalized Platinum Nanoclusters and Their Inhibition Behaviors of Proliferation, Invasion, Migration |
title_full_unstemmed | Distinguishable Targeting of Non‐Small Cell Lung Cancer Using Hyaluronan Functionalized Platinum Nanoclusters and Their Inhibition Behaviors of Proliferation, Invasion, Migration |
title_short | Distinguishable Targeting of Non‐Small Cell Lung Cancer Using Hyaluronan Functionalized Platinum Nanoclusters and Their Inhibition Behaviors of Proliferation, Invasion, Migration |
title_sort | distinguishable targeting of non‐small cell lung cancer using hyaluronan functionalized platinum nanoclusters and their inhibition behaviors of proliferation, invasion, migration |
topic | Full Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409085/ https://www.ncbi.nlm.nih.gov/pubmed/34363352 http://dx.doi.org/10.1002/open.202100070 |
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